BTBR mice exhibit a 100% absence of the corpus callosum and a severely reduced hippocampal commissure.

One of these models is the BTBR T + Itpr3 tf /J mouse. The current review summarizes data gathered in recent research on potential molecular mechanisms responsible for the autism-like behavioral phenotype of this strain. Keywords: BTBR, social behavior, repetitive behavior, neuroanatomy, pharmacological manipulations, molecular mechanisms. 1.

BTBR T+tf /J (BTBR) mice display behaviors consistent with the three diagnostic categories for ASD. They show impaired social interaction and communication as well as increased repetitive behaviors.

Jan 1, 2025 · The BTBR T + Itpr3 tf /J (BTBR) mouse strain manifests a peculiar behavioral phenotype that mirrors the core symptomatology of autism spectrum disorders, including alterations in social-communicative behavioral domains, and the presence of repetitive/stereotyped behaviors. Concurrent immune and metabolic imbalances characterize the …

The inbred mouse strain BTBR T+ tf/J (BTBR) exhibits behavioral deficits that mimic the core deficits of autism. Neuroanatomically, the BTBR strain is also characterized by a complete absence of the corpus callosum.

Apr 17, 2024 · In this regard, the BTBR T+ Itpr3tf/J (BTBR) mice are an inbred mouse strain that exhibits a pattern of behaviours well resembling human ASD-like behavioural features.

May 1, 2017 · BTBR mice display autism-relevant behaviors. Several manipulations ameliorate their social impairments and/or the excess of repetitive behaviors. Multiple signaling pathways are affected. BTBR mice share neuroanatomical features with a subgroup of ASD patients.

Apr 17, 2024 · In this regard, the BTBR T + Itpr3 tf /J (BTBR) mice are an inbred mouse strain that exhibits a pattern of behaviours well resembling human ASD-like behavioural features.

We discovered that the inbred mouse strain BTBR T+tf/J (BTBR) incorporates multiple behavioral phenotypes relevant to all three diagnostic symptoms of autism. BTBR displayed selectively reduced social approach, low reciprocal social interactions and impaired juvenile play, as compared with C57BL/6J (B6) controls.

Aug 15, 2013 · BTBR T+tf /J (BTBR) mice display behaviors consistent with the three diagnostic categories for ASD. They show impaired social interaction and communication as well as increased repetitive behaviors.