We combine classical genetics with modern technology to understand human physiology and search for breakthrough treatments for diseases.

Bruce Beutler, MD, discovered an important family of receptors that allow mammals to sense infections when they occur, triggering a powerful inflammatory response. For this work he received the 2011 Nobel Prize in Physiology or Medicine.

Vikram Jakkamsetti, Qian Ma, Gustavo Angulo, William Scudder, Bruce A Beutler, Juan M Pascual. Genetic influences on motor learning and superperformance mutants revealed by random mutational survey of mouse locomotion bioRxiv. 2023 Jun 29;2023.06.28.546756.

Bruce Beutler, M.D. Director, Center for the Genetics of Host Defense Professor, Immunology. Medical School: University of Chicago. Residency: UT Southwestern Medical Center. Fellowships: Rockefeller University

Apr 11, 2001 · Wang T, Bu CH, Hildebrand S, Jia G, Siggs OM, Lyon S, Pratt D, Scott L, Russell J, Ludwig S, Murray AR, Moresco EMY, Beutler B., Probability of phenotypically detectable protein damage by ENU-induced mutations in the Mutagenetix database.

Bruce Alan Beutler (/ ˈ b ɔɪ t l ər / BOYT-lər; born December 29, 1957) is an American immunologist and geneticist. Together with Jules A. Hoffmann, he received one-half of the 2011 Nobel Prize in Physiology or Medicine, for "discoveries concerning the …

This work entails screening synthetic compounds produced by chemists in the Boger Laboratory for the ability to stimulate the innate immune response in mouse and human macrophages, and in live mice. Those with stimulating activity are isolated and refined to produce highly active innate immune activators.

Dive into the research topics where Bruce A Beutler is active. These topic labels come from the works of this person. Together they form a unique fingerprint.

Bruce BEUTLER, Regental Professor and Director | Cited by 80,748 | of University of Texas Southwestern Medical Center, Dallas (UT Southwestern) | Read 547 publications | Contact Bruce...

TNF knockout rescued hematopoiesis and dramatically reduced splicing defects in RNPS1 hematopoietic cells, demonstrating a surprising link between elevated TNF and defects in splicing caused...