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Monoamine oxidases (MAO) (EC 1.4.3.4) are a family of enzymes that catalyze the oxidation of monoamines, employing oxygen to clip off their amine group. [1][2] They are found bound to the outer membrane of mitochondria in most cell types of the body.

Monoamine oxidase (MAO, EC 1.4.3.4) catalyzes the de-amination of serotonin (5-HT), noradrenaline (NA) and dopamine, monoamine neurotransmitters implicated in a variety of normal and abnormal brain functions (see ref. 1 for a review).

Monoamine oxidase (MAO) (monoamine; oxygen oxidoreductase, deaminating, EC 1.4.3.4) catalyzes the oxidative deamination of a number of biogenic amines in the brain and peripheral tissues by the production of hydrogen peroxide (H 2 O 2) (Shih 1991, Thorpe et al 1987).

The altered brain levels of monoamine neurotransmitters due to monoamine oxidase (MAO) are directly associated with various neuropsychiatric conditions like Alzheimer’s disease (AD). Activated MAO induces the amyloid-beta (Aβ) deposition via abnormal cleavage of the amyloid precursor protein (APP).

Monoamine oxidase is an enzyme that plays a role in breaking down neurotransmitters like serotonin, dopamine, and norepinephrine. It has been shown to be associated with aggression, and is targeted in the treatment of certain mood disorders and neurodegenerative illnesses.

Jul 1, 2021 · Monoamine oxidase inhibitors are promising therapeutic agents for preventing and slowing the progress of neurodegenerative disease. Monoamine oxidase enzymes are responsible for the degredation of serotonin, dopamine, and norepinephrine in the central neurvous system.

Jul 9, 2021 · Monoamine oxidase (MAO) is believed to mediate the degradation of monoamine neurotransmitters, including dopamine, in the brain.

Positron emission tomography (PET) imaging of monoamine oxidases (MAO-A: [(11)C]harmine, [(11)C]clorgyline, and [(11)C]befloxatone; MAO-B: [(11)C]deprenyl-D2) has been actively pursued given clinical importance of MAOs in human neuropsychiatric disorders.

Dec 20, 2023 · The MAOA gene is a gene that plays a role in producing an enzyme called monoamine oxidase A (MAO-A). This enzyme helps to metabolize neurotransmitters like serotonin, norepinephrine, and dopamine in the brain.