The BBB protects brain by blocking the entry of harmful substances from blood and shielding the brain from peripheral fluctuations in hormones, fatty acids and electrolytes. Thus doing, the BBB achieves highly regulated environment in the brain, which is critical for optimal neuronal function.

KEGG is a database resource for understanding high-level functions and utilities of the biological system, such as the cell, the organism and the ecosystem, from molecular-level information, especially large-scale molecular datasets generated by genome sequencing and other high-throughput experimental technologies.

Apr 18, 2017 · Here, we describe a gene expression model, which is representative of the healthy human brain transcriptome by using data from the Allen Brain Atlas. Our in-depth gene expression profiling...

GO term and KEGG pathway analysis of these 95 up-regulated genes revealed categories including “synapse pruning,” “phagosome,” and “complement and coagulation,” suggesting a sustained synapse removal and involvement of the complement system during …

Molecular cloning of a human gene that is a member of the nerve growth factor family. New insights into the role of brain-derived neurotrophic factor in synaptic plasticity. Brain-derived neurotrophic factor in neurodegenerative diseases.

Jun 8, 2017 · Accuracy of brain-coX in predicting KEGG pathways. The displayed accuracy measures were generated from leave-one-out cross-validation using 37 KEGG pathways that function in the human brain. We also examine the effect of requiring a gene to be prioritised in multiple datasets on the accuracy measures.

Conclusions: We report a clinically relevant classification of glioblastoma based on sample level KEGG pathway enrichment profile and this novel classification system provided new insights into the heterogeneity of glioblastoma, and may be used as …

Mar 26, 2021 · Microglia-specific PGC-1α overexpressing mice exhibited significantly decreased neurologic deficits after ischemic injury, with reduced NLRP3 activation and proinflammatory cytokine production. ChIP-Seq analysis and KEGG pathway analysis revealed that mitophagy was significantly enhanced.

Table 4 shows the top KEGG pathways denoting molecular interactions perturbed by MAM in either wild type or Mgmt 2/2 brains. Pathways involved in cancer, Wnt signaling, and insulin- signaling...

Jul 27, 2020 · In this present study, PD mouse model were build and four brain regions (cerebral cortex: CC, hippocampus: HP, striatum: ST, and cerebellum: CB) were separated for RNA-seq analysis.