Ferroptosis shows potential for increasing the responsivity of CBI by inducing immunogenic cell death (ICD) process. Herein, we developed a mitochondrial-targeted liposome loaded with brequinar (BQR) (BQR@MLipo) for enhancing the mitochondrial-related …

Nov 1, 2023 · Furthermore, the in vivo studies revealed that BQR@MLipo could remarkably accumulate into the bladder tumor and successfully initiate the infiltration of CD8 + T cells into tumor microenvironment for enabling efficient CBI to inhibit bladder tumor growth.

Oct 14, 2024 · In this review, we examine recent findings on how lipid metabolic processes, including lipid uptake, synthesis, and oxidation, regulate CD8+ T cells within tumors.

Jun 9, 2024 · Through MHC recognition, CD8 + T cells activate the JAK1/STAT1 pathway in tumor cells, impairing the function of System Xc and reducing GSH and GPX4 expression to promote tumor cell ferroptosis. Additionally, activation of the STAT1-IRF1-ACSL4 pathway could also promote ferroptosis.

In SCLC, BQR blocks pyrimidine metabolism, reducing cell survival in vitro and significantly inhibiting tumor growth in patient-derived xenograft and mouse models [48]. ... thereby reducing immunosuppression in the tumor microenvironment and enabling CD8 + T cells to respond more effectively to immune checkpoint inhibitor therapy [70].

Feb 1, 2022 · Ferroptosis shows potential for increasing the responsivity of CBI by inducing immunogenic cell death (ICD) process. Herein, we developed a mitochondrial-targeted liposome loaded with brequinar (BQR) (BQR@MLipo) for enhancing the mitochondrial-related ferroptosis in bladder cancer in situ. It could be found that BQR@MLipo could selectively ...

Jul 2, 2020 · Each CD8 + Tc subset is functionally distinct and potentially has differential roles during antitumor immune responses. In this review, we provide an overview of the differential roles of each subset, before focusing on the antitumor immune responses they elicit.

Here we review CD8 + T cell differentiation to dysfunctional states during tumorigenesis. We highlight similarities and differences between T cell dysfunction and other hyporesponsive T cell states and discuss the spatio-temporal factors contributing …

Jun 3, 2021 · Our unified atlas of CD8 T cell chromatin and expression states across mouse models and single-cell analyses of the bifurcation between functional and dysfunctional T cell responses will provide a valuable resource to the community and facilitate further mechanistic and translational studies.

Nov 15, 2022 · Here, we used single-cell RNA sequencing (scRNA-seq) to provide a global description of the dynamic metabolic rewiring of CD8 + T cells transitioning in vitro through the activation/differentiation cascade.