Organ-on-a-chip models are based on technological advances in tissue engineering and microfluidics, enabling the reproduction of key features specific to tissue microenvironments within a microfabricated device.

Most of our knowledge of bone cell physiology is derived from experiments carried out in vitro on polystyrene substrates. However, these traditional monolayer cell cultures do not reproduce the complex and dynamic three-dimensional (3D) environment experienced by cells in vivo.

In addition to creating smart bone scaffolds to mitigate bone loss, the field of tissue engineering and regenerative medicine is exploring methods to treat primary and secondary bone malignancies by creating models that mimic the clinical disease manifestation.

Aiming to act as an introductory reference for bone tissue engineers looking to direct their experimental work, this article presents a comprehensive framework of mathematical models on various aspects of bioreactor bone cultures and overviews modelling case studies from literature.

Jul 1, 2021 · Currently, bone tissue engineering is moving from 2D cell culture models such as traditional culture, sandwich culture, micro-patterning, and altered substrate stiffness, towards more complex 3D models including spheroids, scaffolds, cell sheets, hydrogels, bioreactors, and microfluidics chips.

We have developed a novel 3D co-culture model system of bone marrow adipose tissue and myeloma cells that allows for accurate in vitro recapitulation of adipocyte function and adipocyte-myeloma interaction.

Jun 1, 2019 · Traditionally, bone tissue engineering has been used for creating implants for bone regeneration, but recently, it is increasingly applied to create three-dimensional (3D) in vitro bone models to study bone physiology and pathology.

Jan 2, 2025 · This 3D model of microanatomy bone structure provides a highly detailed and anatomically accurate representation of the microscopic features of bone tissue. It highlights key structural components, including compact bone, spongy bone, osteons, Haversian canals, Volkmann's canals, and trabeculae, offering a clear visualization of bone ...

This mechanically intuitive constitutive model is able to describe the loading and unloading of bone very realistically, forms the basis for improved constitutive model developments, and extents future research possibilities.

Oct 1, 2021 · Here we review some key results of bone mechanobiology from computational models, describing the effect that changes associated to the mechanical environment induce in bone response, implant design and scaffold-driven bone regeneration. 1. Introduction.