Bone regeneration repairs bone tissue lost due to trauma, fractures, and tumors, or absent due to congenital disorders. The extracellular matrix (ECM) is an intricate dynamic bio-environment with precisely regulated mechanical and biochemical properties.

May 26, 2020 · In this review, we provide an overview of the function of various types of bone ECMs in bone tissue and their regulation roles in the behaviors of osteoblast-lineage cells and osteoclasts. We also summarize the application of bone ECM in bone repair and regeneration.

Aug 15, 2023 · Here, we introduce the most comprehensive resource of bone extracellular matrix (ECM) proteins that can be used in research fields such as bone regeneration, osteoporosis, and mechanobiology.

The bone, including the extracellular matrix (ECM) is constantly remodeled where ECM components are degraded, modified, and secreted [1]. The balance between degradation and secretion of the bone ECM is important in maintaining bone density, elasticity, and strength [2].

ECM is a naturally occurring substance that includes biochemical and biophysical components in the direct vicinity of the living cells [7]. Bone ECM is primarily composed of type I collagen, the fibrous protein that provides tensile strength, and a mineral referred to as (carbonated) hydroxyapatite that provides compressive strength.

Aug 1, 2015 · This comprehensive review will focus on how networks of ECM proteins function to regulate osteoclast- and osteoblast-mediated bone remodeling. The clinical significance of these networks on normal bone and as they relate to pathologies of …

Apr 3, 2025 · The ECM’s stiffness varies significantly, from a few hundred pascals in fat or brain tissue to gigapascals in bone 13, 20.

Dec 7, 2020 · Bone mineral density, a bone matrix parameter frequently used to predict fracture risk, is not the only one to affect bone fragility. Other factors, including the extracellular matrix (ECM) composition and microarchitecture, are of paramount relevance in this process.

May 25, 2020 · Bone regeneration repairs bone tissue lost due to trauma, fractures, and tumors, or absent due to congenital disorders. The extracellular matrix (ECM) is an intricate dynamic bio-environment with precisely regulated mechanical and biochemical properties.

Dec 17, 2020 · The bone mineralized extracellular matrix (ECM) is predominantly responsible for bone’s resistance to fracture, defined as bone strength. Bone formation or internal reconstruction will determine not only the spatial structure of the tissue but its mechanical properties.