Catenin beta-1, also known as β-catenin (beta-catenin), is a protein that in humans is encoded by the CTNNB1 gene. β-Catenin is a dual function protein , involved in regulation and coordination of cell–cell adhesion and gene transcription .

Beta catenin is a protein encoded by CTNNB1 gene with dual functions in cell adhesion and Wnt signaling

Importantly, the β-catenin-binding site on α-catenin overlaps with α-catenin’s homodimerization interface, hence α-catenin can bind to adherens junctions only in its monomeric state (resulting in an α-catenin/β-catenin heterodimer) (Drees et al, 2005; Yamada et al, 2005).

Jan 3, 2022 · Wnt/β-catenin signalling pathway has shown strong immunosuppressive function in a variety of tumours, and potentially become a novel target of tumour treatment. 300 Using a mouse melanoma...

Most studies investigating catenin actions have focused on α-catenin and β-catenin. β-catenin is particularly interesting as it plays a dual role in the cell. First of all, by binding to cadherin receptor intracellular cytoplasmic tail domains, [ 10 ] it can act as an integral component of a protein complex in adherens junctions that helps ...

Daniels DL, Weis WI. Beta-catenin directly displaces Groucho/TLE repressors from Tcf/Lef in Wnt-mediated transcription activation. Nature structural & molecular biology. 2005;12:364–371. doi: 10.1038/nsmb912. [Google Scholar]

Jun 13, 2012 · β-Catenin (Armadillo in Drosophila) is a multitasking and evolutionary conserved molecule that in metazoans exerts a crucial role in a multitude of developmental and homeostatic processes. More specifically, β-catenin is an integral structural component of cadherin-based adherens junctions, and the …

Kim et al. demonstrated in their study that persistent stabilization of beta-catenin in the dental mesenchyme leads to premature differentiation of odontoblasts and differentiation of cememtoblasts and induces excessive dentine and cementum formation in vivo and suggested that temporospatial regulation of Wnt/β catenin signaling plays critical ...

Homeodomain-interacting protein kinases (Hipks) promote Wnt/Wg signaling through stabilization of beta-catenin/Arm and stimulation of target gene expression

Ikeda S, Kishida S, Yamamoto H, Murai H, Koyama S, Kikuchi A. Axin, a negative regulator of the Wnt signaling pathway, forms a complex with GSK-3beta and beta-catenin and promotes GSK-3beta-dependent phosphorylation of beta-catenin.