The BCL2 product consists of two green 161kb, 196kb probes and two red 304kb, 176kb probes, which are positioned on each side of the BCL2 gene.

Hybridization of this probe to interphase nuclei of normal cells is expected to produce two pair of overlapping, or nearly overlapping, orange and green (yellow fusion) signals. Normal Hybridization: Normal cell hybridization using the LSI BCL2 Dual Color Break Apart Rearrangement Probe.

XL BCL2 BA consists of an orange-labeled probe hybridizing proximal to the BCL2 gene region at 18q21.3 and a green-labeled probe hybridizing distal to the BCL2 gene region at 18q21.3.

The reciprocal translocation t (14;18) (q32;q21) can be detected in about 85% of FL patients and in up to 35% of patients with DLBCL. t (14;18) juxtaposes BCL2 to transcriptional enhancers in the IGH locus and results in overexpression of the BCL-2 protein in neoplastic follicles.

The IGH/BCL2 product consists of probes, labelled in green, covering the Constant, J, D and Variable segments of the IGH gene, and a 585kb probe, labelled in red, covering the BCL2 and KDSR genes.

The Zyto Light SPEC BCL2 Dual Color Break Apart Probe (PL150) is intended to be used for the qualitative detection of translocations involving the human BCL2 gene at 18q21.33 in formalin-fixed, paraffin-embedded specimens, such as B-cell lymphoma, by fluorescence in situ hybridization (FISH).

BCL2 IQFISH Break-Apart Probe is intended for the detection of rearrangements involving the BCL2 gene by fluorescence in situ hybridization (FISH). The probe is to be used on formalin-fixed, paraffin-embedded tissue sections.

The ZytoLight ® SPEC BCL2/IGH Dual Color Dual Fusion Probe is designed to detect the translocation t (14;18) (q32;q21) affecting the BCL2 gene in the chromosomal region 18q21.33 and the IGH locus in 14q32.33 by Fluorescence in situ Hybridization (FISH).

Vysis LSI IGH/BCL2 Dual Color Dual Fusion Probes. For more information, contact Abbott. The expected pattern in a normal nucleus hybridized with the LSI IGH/BCL2 probe is the two orange, two green signal pattern (2O2G).

The BCL2 break apart probe is designed to detect chromosomal rearrangements involving the BCL2 gene on chromosome 18. The BCL2 gene is a proto-oncogene that encodes an anti-apoptotic signaling protein1.