The BCL-2 family has four main functions: inhibitory effects (BCL-2, BCL-Xl, BCL-W, BCL2-A1, and MCL-1), activation (BIM and PUMA), effector (BAX and BAK), and sensitization (NOXA).

Myeloid leukemia 1 (MCL-1) is an antiapoptotic protein of the BCL-2 family that prevents apoptosis by binding to the pro-apoptotic BCL-2 proteins. Overexpression of MCL-1 is frequently observed in many tumor types and is closely associated with tumorigenesis, poor prognosis and drug resistance.

Sep 2, 2021 · MCL1 (myeloid cell leukemia-1) is a widely recognized pro-survival member of the Bcl-2 (B-cell lymphoma protein 2) family and a promising target for cancer therapy. While the role MCL1...

Omacetaxine mepesuccinate (a drug approved for the treatment for chronic myelogenous leukemia) and Seliciclib [12] (which is under investigation as a potential multiple myeloma treatment) both act in part by inhibiting synthesis of Mcl-1. MCL1 has been identified as a resistance factor for BCL-2 inhibitor venetoclax in lymphoma cells. Therefore, new strategies of combining BCL-2 and MCL1 ...

Jan 15, 1997 · Mcl-1 is a member of the Bcl-2 family that was identified based on increased expression in myeloblastic leukemia cells undergoing differentiation. Mcl-1 was previously found to be similar to Bcl-2 in causing a delay in apoptotic cell death in Chinese hamster ovary cells.

Apr 24, 2019 · Our data show for the first time that therapies targeting specific combinations of BCL-2 pro-survival proteins, namely MCL-1 plus BCL-XL and MCL-1 plus BCL-2, could have significant...

Jan 6, 2020 · MCL1 is the first antiapoptotic gene for which homology to BCL2 was reported. Mcl-1 plays a significant role in the inhibition of apoptosis and demonstrates oncogenic properties. Mcl-1 is a...

The 20 or so members of the family have been identified and classified according to their function in apoptosis. 3 Classically, three subgroups have been defined: (i) the prosurvival Bcl-2 proteins, such as Bcl-2 itself, Bcl-xL, Bcl-w, Mcl-1 and A1, which inhibit cell death through direct interactions with the proapoptotic members; (ii) the ...

In multiple myeloma cell lines (n = 21), BCL-2 is expressed but sensitivity to venetoclax correlated with high BCL-2 and low BCL-XL or MCL-1 expression. Multiple myeloma cells that coexpress BCL-2 and BCL-XL were resistant to venetoclax but sensitive to a …

Mar 1, 2019 · Myeloid Cell Leukemia 1 (MCL-1) was cloned from a human myeloid leukemia cell line during TPA-induced differentiation (Kozopas, Yang, Buchan, Zhou, & Craig, 1993). Based on the sequence homology, it belongs to the Bcl-2 family of anti-apoptotic genes, such as Bcl-2, Bcl-2 L10, Bcl-W and Bcl-xL (Kelekar & Thompson, 1998).