The Bcl-2 family (TC# 1.A.21) consists of a number of evolutionarily-conserved proteins that share Bcl-2 homology (BH) domains. The Bcl-2 family is most notable for their regulation of …

Bcl-2, encoded in humans by the BCL2 gene, is the founding member of the Bcl-2 family of regulator proteins. BCL2 blocks programmed cell death (apoptosis) [5] while other BCL2 family …

The BCL-2 family has four main functions: inhibitory effects (BCL-2, BCL-Xl, BCL-W, BCL2-A1, and MCL-1), activation (BIM and PUMA), effector (BAX and BAK), and sensitization (NOXA). …

Nov 17, 2017 · We highlight the core mechanisms of BCL-2 family regulation of MOMP with an emphasis on how the interactions between the BCL-2 family proteins govern cell fate.

Jul 12, 2023 · In this Review, we revisit the most important advances in the field and integrate them into a new structure–function-based classification of the BCL-2 family members that …

BCL-2 family proteins are the regulators of apoptosis, but also have other functions. This family of interacting partners includes inhibitors and inducers of cell death. Together they regulate and …

Therapies that directly target the apoptotic response by inhibiting anti-apoptotic BCL-2 family proteins (e.g. navitoclax, ABT-199) have shown clinical promise for cancers that depend on …

Feb 21, 2019 · BCL-2 family members play an integral role in apoptosis, but also contribute to many other cellular functions. Isoforms of almost all of the BCL-2 family members have been …

The Bcl-2 family is defined by homology shared within four conserved regions in Bcl-2, termed BCL-2 homology (BH) domains, and is grouped into three subfamilies depending on their …

The BCL-2 family, comprised of both pro-apoptotic and anti-apoptotic members, acts as a checkpoint upstream of CASPASES and mitochondrial dysfunction. BID and BAD possess the …