Bcl-2-like protein 11, commonly called BIM (B cl-2 I nteracting M ediator of cell death), is a protein that in humans is encoded by the BCL2L11 gene. [5][6] The protein encoded by this gene belongs to the BCL-2 protein family.

Jan 15, 1998 · An expression screen for proteins that bind to Bcl-2 yielded a small novel protein, denoted Bim, whose only similarity to any known protein is the short (nine amino acid) BH3 motif shared by most Bcl-2 homologues.

Jul 7, 2007 · We examined the role of the antiapoptotic molecule Bcl-2 in combating the proapoptotic molecule Bim in control of naive and memory T cell homeostasis using Bcl-2−/− mice that were additionally deficient in one or both alleles of Bim.

The BCL-2 family has four main functions: inhibitory effects (BCL-2, BCL-Xl, BCL-W, BCL2-A1, and MCL-1), activation (BIM and PUMA), effector (BAX and BAK), and sensitization (NOXA).

Here, we used CD4CreBcl2 f/f mice to define the role of the anti-apoptotic protein, Bcl-2, and CD4CreBcl2 f/f Bim f/f mice to determine the role of Bcl-2 in opposing Bim to promote survival of IELp.

Three Bim isoforms, probably generated by alternative splicing, all induce apoptosis, the shortest being the most potent. Wild‐type Bcl‐2 associates with Bim in vivo and modulates its death function, whereas Bcl‐2 mutants that lack survival function do neither.

Jun 1, 2016 · The interactions of BCL-2 family (pro- and anti-apoptotic) proteins critically regulate cell survival and apoptosis [1], [2], [3], [4]. The BH3-only proteins of BCL-2 family transmit pro-cell death signals arising from different stimuli.

Nov 26, 1999 · Apoptosis can be triggered by members of the Bcl-2 protein family, such as Bim, that share only the BH3 domain with this family. Gene targeting in mice revealed important physiological roles for Bim.

Apr 9, 2025 · Subsequent work from Andreas, Philippe Bouillet, Anselm Enders, David Tarlinton, Suzanne Cory and Jerry Adams revealed that BCL-2 over-expression or loss of one of its inhibitors, BIM (see below ...

Bcl-2 family members that have only a single Bcl-2 homology domain, BH3, are potent inducers of apoptosis, and some appear to play a critical role in developmentally programmed cell death. We examined the regulation of the proapoptotic activity of the BH3-only protein Bim.