Bcl-xL - Wikipedia
B-cell lymphoma-extra large (Bcl-xL), encoded by the BCL2-like 1 gene, is a transmembrane molecule in the mitochondria. It is a member of the Bcl-2 family of proteins, and acts as an anti …
Development of a BCL-xL and BCL-2 dual degrader with …
Nov 25, 2021 · Using this approach to guide our development of a series of ABT263-derived and VHL-recruiting PROTACs, we generate a potent BCL-xL and BCL-2 (BCL-xL/2) dual degrader …
The role of BCL-2 family proteins in regulating apoptosis and …
The BCL-2 family has four main functions: inhibitory effects (BCL-2, BCL-Xl, BCL-W, BCL2-A1, and MCL-1), activation (BIM and PUMA), effector (BAX and BAK), and sensitization (NOXA). …
Bcl-2 and Bcl-xL play important roles in the crosstalk between ...
Bcl-2 and Bcl-xL, the well-characterized apoptosis guards, appear to be important factors in autophagy, inhibiting Beclin 1-mediated autophagy by binding to Beclin 1. In addition, Beclin 1, …
Bcl-xL/Bcl-2 coordinately regulates apoptosis, cell cycle arrest and ...
Bcl-2 targeted to the endoplasmic reticulum and mitochondria delayed cell cycle entry. Bcl-2 protein is found in the mitochondrial outer membrane, endoplasmic reticulum (ER) and nuclear …
BCL-xL/BCL2L1 is a critical anti-apoptotic protein that ... - Nature
May 18, 2020 · Here, we profiled the expression of BCL-2 family of proteins during pancreatic specification and observed an upregulation of BCL-xL, downregulation of BAK and …
Antileukemia efficacy of the dual BCL2/BCL-XL inhibitor AZD0466 …
Feb 4, 2025 · The upregulation of B-cell lymphoma 2 (BCL2) and B-cell lymphoma–extra large (BCL-XL), 2 proteins in the BCL2 family of proteins, leads to a disproportional expression of …
Development and crystal structures of a potent second-generation …
Mar 29, 2024 · In this study, we set out to determine the molecular basis by which 753b mediates targeted degradation of BCL-xL/BCL-2 and determined crystal structures of both …
The BCL-2 protein family: from discovery to drug development
Although the BCL-2 inhibitor Venetoclax is in clinical use and inhibitors of BCL-XL and MCL-1 are undergoing clinical trials, several questions remain on whether therapeutic windows can be …
Bcl-2 and Bcl-xL in Diabetes: Contributions to Endocrine
Jan 17, 2025 · This review summarizes the roles of Bcl-2 and Bcl-xL in apoptosis and metabolic homeostasis. It focuses on how the dysregulation of Bcl-2 and Bcl-xL affects pancreatic β-cell …