Role for B-cell adapter for PI3K (BCAP) as a signaling adapter …
Jan 3, 2012 · Our results demonstrate that BCAP is a unique TIR domain-containing TLR signaling adapter crucial for linking TLRs to PI3K activation and regulating the inflammatory …
B cell adapter for PI 3-kinase (BCAP) coordinates antigen ... - AAAS
Nov 15, 2024 · We and others have shown that BCAP is required for TLR-mediated PI3K activation in macrophages (5, 6), and, in plasmacytoid dendritic cells (pDCs), BCAP promotes …
B cell adaptor for PI3-kinase (BCAP) modulates CD8 - PubMed …
We show that initial PI3K signaling during T cell activation results in up-regulation of the signaling scaffold B cell adaptor for PI3K (BCAP), which further potentiates PI3K signaling and …
Role for B-cell adapter for PI3K (BCAP) as a signaling adapter ... - PNAS
Dec 20, 2011 · We find that BCAP has a functional N-terminal TIR homology domain and links TLR signaling to activation of PI3K. In addition, BCAP negatively regulates proinflammatory …
BCAP: Immunity - Cell Press
Dec 1, 2000 · Tyrosine phosphorylation of adaptor proteins permits the B cell antigen receptor (BCR)-associated protein tyrosine kinases to regulate downstream effector molecules. Here, …
Toll-like receptors, signaling adapters and regulation of the pro ...
Selective genetic disruption of TLR mediated activation of PI3K, through BCAP deficiency in specific cell types via Cre-Lox technology, could give more insight into the particular role of …
B-cell adaptor for PI3K (BCAP) negatively regulates Toll-like …
Jan 1, 2012 · Here, we show that the signaling adapter B-cell adaptor for PI3K (BCAP) links TLR signaling to PI3K activation. BCAP-deficient macrophages and mice are hyperresponsive to …
BCAP links IL-1R to the PI3K–mTOR pathway and regulates pathogenic …
To determine whether BCAP is required for activation of the PI3K pathway downstream of IL-1R, we activated pure CD4 + T cells using plate-bound αCD3 + αCD28 to induce up-regulation of …
MyD88 determines T cell fate through BCAP-PI3K signaling
Our data demonstrate that MyD88 acts downstream of the TCR to regulate T cell fate through its association with BCAP and elucidate a novel molecular mechanism for MyD88 in T cell biology …
BCAP: The Tyrosine Kinase Substrate that Connects B
Dec 1, 2000 · Tyrosine phosphorylation of adaptor proteins permits the B cell antigen receptor (BCR)-associated protein tyrosine kinases to regulate downstream effector molecules. Here, …