Mar 28, 2025 · BATF3 (Basic Leucine Zipper ATF-Like Transcription Factor 3) is a Protein Coding gene. Diseases associated with BATF3 include Hematologic Cancer and Dendritic Cell Deficiency. Among its related pathways are Calcineurin-regulated NFAT-dependent transcription in lymphocytes and Pre-implantation embryo.

Mechanistically, BATF3 regulated T cell apoptosis and longevity via the proapoptotic factor BIM. By programing CD8 + T cell survival and memory, BATF3 is a promising molecule to optimize adoptive T cell therapy in patients.

Sep 28, 2020 · By programing CD8+ T cell survival and memory, BATF3 is a promising molecule to optimize adoptive T cell therapy in patients. BATF3 is a member of the AP-1 transcription factor family.

Here we show that the transcription factor Batf3 acts as a fate-decision factor with respect to Tconv versus Tregs by restraining Treg differentiation. Batf3 was preferentially expressed in effector CD4 T cells but not in Treg cells, and ectopic expression of …

Feb 8, 2025 · Basic Leucine Zipper ATF-Like Transcription Factor 3 (BATF3), an AP-1 family transcription factor, is a glucocorticoid receptor coregulator whose interaction with glucocorticoid receptor is modulated by the lever arm.

Batf3−/− memory cells had an impaired ability to mount a robust recall response but remained functional. These findings reveal a novel cell intrinsic role of Batf3 in regulating CD8 T cell memory development.

Batf3 (p21SNFT) was highly expressed in cDCs, with low to absent expression in other immune cells and non-immune tissues. Thus, we generated Batf3-/-mice lacking expression of the Batf3 protein .

The transcription factor, known as basic leucine zipper ATF-like 3 (BATF3), is a crucial contributor to the development of conventional type 1 dendritic cells (cDC1), which is definitely required for priming CD8 + T cell-mediated immunity against intracellular pathogens and malignancies.

Jan 28, 2025 · Essential role for Batf3-dependent dendritic cells in regulating CD8 T-cell response during SARS-CoV-2 infection. Donor Batf3 inhibits murine lung allograft rejection and airway fibrosis. The bZIP transcription factor BATF3/ZIP-10 suppresses innate immunity by attenuating PMK-1/p38 signaling.

May 1, 2024 · We find that enforced overexpression of Batf3 cDNA using a retroviral vector in virus-specific IL-2Rα-/-CD8 + T cells greatly enhanced their capacity for survival into the contraction phase of primary infection.