Transcription regulator protein BACH2 (broad complex-tramtrack-bric a brac and Cap'n'collar homology 2) is a protein that in humans is encoded by the BACH2 gene. [5][6][7] It contains a …

Mar 28, 2025 · BACH2 (BTB Domain And CNC Homolog 2) is a Protein Coding gene. Diseases associated with BACH2 include Immunodeficiency 60 And Autoimmunity and …

Bach2 is a highly conserved member of the basic and leucine zipper domain (bZIP) superfamily of transcription factors (TFs); it regulates transcriptional activity in T- and B-lymphocyte …

Jun 10, 2013 · Scientists discovered how a gene called BACH2 may affect the development of multiple sclerosis, asthma, Crohn's disease, celiac disease and other allergic and autoimmune …

Jun 2, 2013 · Here, by studying mice in which the Bach2 gene is disrupted, we define BACH2 as a broad regulator of immune activation that stabilizes immunoregulatory capacity while …

Here, we reveal a critical role of Bach2 in regulating T cell biology and the correlation with these immune-mediated diseases. 1. Introduction. Transcription factors play key roles in the …

Feb 11, 2021 · Single-cell transcriptomic and epigenomic approaches revealed that BACH2 established the transcriptional and epigenetic programs of stem-like CD8 + T cells. In addition, …

Emerging evidence suggest a critical role of the transcription factor Bach2 in regulating Th2 immune responses. Bach2 serves as a super enhancer and transcriptional repressor to control …

May 22, 2024 · In this review, we focus on the role of BACH2 in T cell fate and iTreg function and stability. We suggest approaches to modulate BACH2 function that may lead to more stable …

Bach2 has been previously thought to mediate its main action through stimulation of the T cell receptor. Now, these new findings highlight that Bach2 plays multiple roles in dictating the fate …