Dec 15, 2022 · BRD4-NUT is an oncogenic fusion protein of the acetyl lysine reader BRD4 that binds to the acetylase p300 and enables formation of long-range intra- and interchromosomal interactions. We here...

Jun 17, 2019 · Among these, the enhancer regulators P300 and Brd4 can prematurely activate transcription and restore transcriptional competency when maternal mRNA translation is blocked, whereas inhibition of histone acetylation blocks genome activation.

Jan 24, 2023 · BRD4-NUT, a driver fusion mutant in rare and highly aggressive NUT carcinoma, acts in aberrant transcription of anti-differentiation genes by recruiting histone acetyltransferase (HAT) p300 and...

Dec 22, 2023 · The dual BRD4 and CBP/p300 bromodomain co-inhibitor XP-524 exhibits higher potency and superior tumoricidal activity than the BRD4 inhibitor JQ-1, and shows anticancer efficacy comparable to...

Here, we show that transcriptional competency is regulated by Brd4 and p300-dependent histone acetylation in zebrafish. Live imaging of transcription revealed that genome activation, beginning at the miR-430 locus, is gradual and stochastic.

Nov 13, 2018 · Wu et al. find that Brd4’s bromodomains partner with the histone acetyltransferase P300 to augment its enzymatic activity. Brd4-P300 interaction recruits Brg1 to modify chromatin structure of pluripotency-associated genes in embryonic stem cells.

Nov 13, 2018 · Here, we show that Brd4's bromodomains partner with the histone acetyltransferase P300, increasing its enzymatic activities. Augmenting histone acetylation by Brd4-P300 interaction recruits the chromatin remodeler Brg1 altering chromatin structure.

Here, we show that transcriptional competency is regulated by Brd4- and P300-dependent histone acetylation in ze-brafish. Live imaging of transcription revealed that genome activation, beginning at the miR-430 locus, is gradual and stochastic.

Jan 24, 2023 · BRD4-NUT, a driver fusion mutant in rare and highly aggressive NUT carcinoma, acts in aberrant transcription of anti-differentiation genes by recruiting histone acetyltransferase (HAT) p300 and promoting p300-driven histone hyperacetylation and nuclear condensation in …

Jun 17, 2019 · Here, we show that transcriptional competency is regulated by Brd4- and P300-dependent histone acetylation in zebrafish. Live imaging of transcription revealed that genome activation, beginning at the miR-430 locus, is gradual and stochastic.