Nov 12, 2019 · Blunting BRD4 by JQ1 alleviated ischemic stroke in mice following MCAO by reducing glial activation, inflammation and pyroptosis, which indicated that BRD4 might serve as a promising therapeutic target for stroke treatment.

Nov 12, 2019 · Suppressing BRD4 by JQ1 reduced the infarction volume, brain water contents and neurological deficit score of MCAO mice. In addition, MCAO-induced glial activation was also blunted by JQ1, as proved by the significantly reduced expression of glial fibrillary acidic protein (GFAP) and Iba-1.

Dec 1, 2020 · In rats MCAO/R model, hispidulin treatment ameliorated neurological dysfunction by alleviating pyroptosis in the ischemic cortex. This neuroprotective effect was modulated via AMPK activation and GSK3β inhibition, which was confirmed …

Nov 12, 2019 · Suppressing BRD4 by JQ1 reduced the infarction volume, brain water contents and neurological deficit score of MCAO mice. In addition, MCAO-induced glial activation was also blunted by JQ1, as proved by the significantly reduced expression of glial fibrillary acidic protein (GFAP) and Iba-1.

Dec 15, 2022 · BRD4 knockdown by adenovirus inhibited fibrous scarring, promoted synaptic survival, decreased the infarct volume, and improved neurological function after MCAO/R injury. Moreover, inhibition of BRD4, either by JQ1 in vitro or adenovirus in vivo, decreased the phosphorylation of Smad2/3.

Here, our results showed that CK2 regulates fibrous scar formation after MCAO/R injury by affecting BRD4 phosphorylation. Therefore, CK2 may play multiple roles through multiple signaling pathways or through the phosphorylation of multiple substances in different organs.

While JQ1 decreases BRD4 expression in the MCAO model, it mitigates against the pyrin domain-containing protein 3 (NLRP3) inflammasome-mediated inflammatory response and pyroptosis, inhibits glial activation, and ultimately eased MCAO-induced brain injury.

Jan 24, 2022 · RiPC is a protective method for brain damage. This study is to explore the effect and mechanism of RiPC in cerebral ischemia injury in rats through regulation of miR-204-5p/BRD4 expression. Middle cerebral artery occlusion (MCAO) rat model and glucose deprivation (OGD) neuron model were established.

Using a middle cerebral artery occlusion model (MCAO) of ischemic stroke, BRD4 and inflammatory cytokines (Il-1b, Il-6, Il-18, and Tnf-a) were found to be significantly elevated in mouse brain tissue (Zhou et al., 2019).

Dec 15, 2022 · BRD4 knockdown by adenovirus inhibited fibrous scarring, promoted synaptic survival, decreased the infarct volume, and improved neurological function after MCAO/R injury. Moreover, inhibition of BRD4, either by JQ1 in vitro or adenovirus in vivo, decreased the phosphorylation of Smad2/3.