Jul 22, 2019 · Next, we explored the role of BRD4 in regulation of MAPK, NF-κB signaling, and autophagy. The results showed that BRD4 is the upstream regulator of all of these 3 factors, and inhibition of BRD4 may suppress MAPK and NF-κB signaling while …

Next, we explored the role of BRD4 in regulation of MAPK, NF-κB signaling, and autophagy. The results showed that BRD4 is the upstream regulator of all of these 3 factors, and inhibition of BRD4 may suppress MAPK and NF-κB signaling while activating autophagy in …

Nov 21, 2024 · We report that activation of the MAPK/JNK pathway results in JNK-mediated phosphorylation of BRD4 at three distinct sites within the C-terminal domain of BRD4. This phosphorylation triggers the release of BRD4 from chromatin and its recruitment to and transcriptional activation of critical inflammatory genes.

Jun 26, 2021 · Bromodomain-containing protein 4 (BRD4) has emerged as a promising treatment target for bone-related disorders. (+)-JQ1, a thienotriazolodiazepine compound, has been shown to inhibit...

BRD4 function is partially regulated by p38 mitogen-activated protein kinase (MAPK) . Fortunately, Matthew S. Stratton et al. reported that microRNA-9 is able to target the 3'UTR of the BRD4 transcript.

Wang J, Hu J, Chen X, Huang C, Lin J, Shao Z, Gu M, Wu Y, Tian N, Gao W, et al. BRD4 inhibition regulates MAPK, NF-κB signals, and autophagy to suppress MMP-13 expression in diabetic intervertebral disc degeneration.

Mar 25, 2025 · These findings highlight the crucial role of the BRD4/MAP2K7/PGF signaling axis in cellular senescence and ECM regulation, suggesting that BRD4 represents a promising therapeutic target for IDD.

In this study, we uncover a role of MOK kinase in controlling inflammatory and type-I interferon (IFN) responses in microglia via a Brd4 (bromodomain-containing protein 4)-dependent mechanism and report that MOK-mediated immune functions are dysregulated, and actively participate, in ALS pathophysiology.

May 14, 2022 · Mechanistically, MZ1 exhibits anti-tumor effect in NB cells by suppressing the expression of N-Myc or C-Myc as well as the MAPK signaling pathway. Overall, our data imply that MZ1 might be exploited as a possible therapeutic method for NB therapy.

Jul 11, 2023 · In this work, we reveal that MAPK/MAK/MRK overlapping kinase (MOK), with an unknown physiological substrate, displays an immune function by controlling inflammatory and type-I interferon (IFN) responses in microglia which are detrimental to primary motor neurons.