The CUT&Tag assay of BRD4 and H3K27ac, revealed that BRD4 inhibition disrupted the super-enhancers (SEs) of IRF4 (a crucial transcription factor for M2 macrophage), and subsequently …

Jan 31, 2025 · The CUT&Tag assay of BRD4 and H3K27ac, revealed that BRD4 inhibition disrupted the super-enhancers (SEs) of IRF4 (a crucial transcription factor for M2 …

These findings provide insight into the role of BRD4 in epigenetic regulation of gene pathways that promote the metastatic phenotype of cancer cells and suggest that therapies targeting BRD4 …

Apr 14, 2020 · NHWD-870 inhibits CSF1 expression through suppressing BRD4 and its target HIF1α. Taken together, these results reveal a mechanism by which BRD4 inhibition …

May 1, 2023 · By analysis of the TIMER database, a positive correlation between BRD4 expression and macrophage infiltration was established, and BRD4 may regulate the …

Jun 1, 2022 · Through analysis of the TIMER database, we found that increased BRD4 gene expression, high-density macrophages infiltration and high-density M2 macrophages infiltration …

Taken together, our work demonstrates the versatile role and therapeutic efficacy of SPP-ARV-825 micelle against glioma, which may provide a novel strategy for glioma therapy in future. …

Feb 28, 2020 · AZD5153 inhibiting BRD4, as a potential therapeutic strategy for HGSOC, was demonstrated to confer controversial plasticity on TAMs, which shows the need to uncover its …

Feb 28, 2020 · This antitumor immunity is attributed to the suppression of BRD4 at the MAF binding site in macrophages. Thus, AZD5153 disassembled BRD4 to suppress MAF and its …

Jan 9, 2024 · BRD4 inhibition suppressed M2 macrophage polarization. Particularly, we deeply investigated the underlying molecular mechanism of how BRD4 epigenetically regulate M2 …