Brd4 binds to active enhancers to control cell identity gene …
Dec 20, 2017 · Using two conditional knockout mouse strains and derived cells, we demonstrate that Brd4 controls cell identity gene induction and is essential for adipogenesis and myogenesis. Brd4...
RUNX2 expression in thyroid and breast cancer requires the
Nov 2, 2017 · We showed that BRD4 controls RUNX2 by binding to the newly identified ENHs and we demonstrated that the anti-proliferative effects of bromodomain inhibitors (BETi) is associated with RUNX2 transcriptional repression.
Phosphorylation by JNK switches BRD4 functions - Cell Press
Nov 21, 2024 · In response to diverse stimuli, c-Jun N-terminal kinase (JNK)-mediated phosphorylation of human BRD4 at Thr1186 and Thr1212 triggers its transient release from chromatin, disrupting its HAT activity and potentiating its kinase activity.
Methylation of BRD4 by PRMT1 regulates BRD4 phosphorylation …
Sep 22, 2023 · Here we report that BRD4 is asymmetrically methylated at R179/181/183 by PRMT1, which is antagonized by the Jumonji-family demethylase, JMJD6. PRMT1 is overexpressed in ovarian cancer tissue and...
Arginine Methylation of BRD4 By CARM1 Regulates Its Function in …
Nov 2, 2023 · We identified over 500 interactors of CARM1, many of which are novel, including one particularly promising therapeutic target, bromodomain-containing protein 4 (BRD4).
Inhibition of BRD4 suppresses the malignancy of breast cancer …
May 21, 2019 · We found that targeted inhibition of BRD4 reduces migration, invasion, in vivo growth of patient-derived xenograft (PDX), and lung colonization of breast cancer (BC) cells. Inhibition of BRD4...
Flipping a switch on BRD4: How to control the do-it-all - Cell Press
Nov 21, 2024 · Here, the Singer laboratory identifies a molecular switch that converts BRD4 from a chromatin remodeler to a transcription activator . The study demonstrates c-Jun N-terminal kinase (JNK) to phosphorylate serine (Ser) and threonine (Thr) residues in the C terminus of mammalian BRD4.
BRD4 and MYC—clarifying regulatory specificity | Science - AAAS
May 18, 2018 · BRD4 and MYC (as a dimer with MAX; not shown here) are broadly bound to the regulatory regions of active genes. Whereas BRD4 degradation affects transcription of all genes, MYC is only required at select loci, enriched for genes involved in cell growth and proliferation.
We demonstrate that inhibition of BRD4 results in synergistic responses to PARPi, reversing intrinsic resistance in RAS mutant tumors as well as additional mechanisms of PARPi resistance. Thus PARPi and BRD4i
Discovery of RSV-Induced BRD4 Protein Interactions Using Native ...
Our results demonstrate that BRD4 recruits several inflammation-modulating transcription factors during RSV infection, including ββ-catenin of the Wnt-signaling pathway and c-JUN (JUN) and Fos-Related Antigen 1 (FOSL1) of the AP1 complex.