Inhibition of BRD4, IFNG, TNF, IL12, CD40LG, and FLT3LG, as well as activation of EGR2, FOXO3, CD38, IL1RN, and IL5 pathways were among the most significant effects predicted by differentially expressed genes (Supplementary Table S6B).

Jul 21, 2021 · Here, we show that cancer-associated fibroblast (CAF)-activated stromal signaling, interleukin-6/8-JAK2, induces BRD4 phosphorylation at tyrosine 97/98 in colorectal cancer, resulting in BRD4...

Apr 9, 2025 · We analyze open reading frame screen data and find that overexpression of BRD4 long (BRD4-L) and short isoform BRD4-S (a) impairs cell growth across cell lines. We confirm these results in OVSAHO ovarian cancer cells, where the overexpression of BRD4 isoforms significantly reduces tumor growth.

We demonstrate that inhibition of BRD4 results in synergistic responses to PARPi, reversing intrinsic resistance in RAS mutant tumors as well as additional mechanisms of PARPi resistance.

Dec 22, 2023 · Small molecule compound BRD4 BD1 and BD2 bromodomain inhibitors block BRD4 binding to super-enhancers, suppress oncogene transcription and expression, reduce cancer cell proliferation and...

Sep 28, 2023 · BRD4 protects DLBCL cells from ferroptosis by positively regulating the expression of FSP1. BET inhibitors increase the susceptibility of GCB-DLBCL cells to ferroptosis and thus promote the toxicity of DMF both in vitro and in vivo.

Binding of BRD4 to the RORC promoter directly enhances IL-17 and IL-22 transcript expression and this was reversed by targeted inhibition of BRD4, providing a potential mechanism by which BRD4 may control the expression of pro-inflammatory cytokines …

Indeed, Brd2 is distinct from Brd4 in its co-localization with CTCF, with ∼3-fold more peaks and higher intensity (Figure 2B), and conversely, Brd4 displays higher intensity with Stat3 than Brd2 (Figure S2A), as illustrated at Il17a, Rorc, Il9, and Il12rb1 (Figures 2C and S2B).

We examined whether and how targeting bromodomain containing 4 (BRD4) inhibits chemoradiation‐induced PD‐L1 expression and evaluated the effect of BRD4 inhibition and chemoradiation combination in vivo.

Apr 1, 2018 · Bromodomain and extra-terminal (BET) family proteins are key regulators of gene expression in cancer. Herein, we utilize BRD4 profiling to identify critical pathways involved in pathogenesis of chronic lymphocytic leukemia (CLL).