Bromodomain-containing protein 4 (BRD4) as an epigenetic
Oct 29, 2022 · In this study, BRD4-binding proteins were obtained through co-immunoprecipitation (Co-IP) and mass spectrum (MS) to identify the co-regulators with BRD4 …
BRD4 (E2A7X) Rabbit mAb | Cell Signaling Technology
3 days ago · Monoclonal Antibody for studying BRD4 isoform A. Validated for C&R, C&T, ChIP, ChIP, IHC, IP, WB, eCLIP. Available in 2 sizes. Highly specific and rigorously validated in …
Brd4 binds to active enhancers to control cell identity gene …
Dec 20, 2017 · Using two conditional knockout mouse strains and derived cells, we demonstrate that Brd4 controls cell identity gene induction and is essential for adipogenesis and …
Distinct layers of BRD4-PTEFb reveal bromodomain ... - Cell Press
Aug 17, 2023 · We first carried out GFP IP for the GFP-tagged, FL BRD4 upon dCDK9 treatment. CDK9 degradation also impairs BRD4-CCNT1 interaction, indicating the requirement of CDK9 …
Stromal induction of BRD4 phosphorylation Results in Chromatin ...
Jul 21, 2021 · Here, we show that cancer-associated fibroblast (CAF)-activated stromal signaling, interleukin-6/8-JAK2, induces BRD4 phosphorylation at tyrosine 97/98 in colorectal cancer, …
SMARCA4 regulates inducible BRD4 genomic redistribution …
Mar 25, 2025 · The following antibodies were used in immunoprecipitation (IP): IRF1 (Proteintech 11335–1-AP), BRD4 (Cell Signaling 13 440) and SMARCA4 (Proteintech, 11335–1-AP); IgG …
The Bromodomain Protein 4 Contributes to the Regulation of ... - PubMed
Nov 19, 2019 · The bromodomain protein 4 (BRD4) is an atypical kinase and histone acetyl transferase (HAT) that binds to acetylated histones and contributes to chromatin remodeling …
BRD4 regulates m6A of ESPL1 mRNA via interaction with ALKBH5 …
Mar 1, 2025 · We found that targeted inhibition of bromodomain-containing protein 4 (BRD4) by siRNA or its inhibitor (JQ1) significantly decreases mRNA m 6 A levels and suppresses the …
The Bromodomain Protein 4 Contributes to the Regulation of …
Nov 19, 2019 · Importantly, BRD4 interacts with components of the splicing machinery, as assessed by both immunoprecipitation (IP) and proximity ligation assays (PLAs), and co …
Phospho Switch Triggers Brd4 Chromatin Binding and Activator ...
Mar 7, 2013 · To demonstrate the intramolecular regulation of Brd4 chromatin-binding activity in vivo, we transfected each f:Brd4 expression plasmid into 293 cells, performed M2-IP followed …