Bromodomain-containing protein 4 is a protein that in humans is encoded by the BRD4 gene. [5] [6] BRD4 is a member of the BET (bromodomain and extra terminal domain) family, which also includes BRD2, BRD3, and BRDT. [7] BRD4, similar to other BET family members, contains two bromodomains that recognize acetylated lysine residues. [8]

Jan 19, 2021 · The bromodomain and extraterminal domain (BET) family of proteins consists of four conserved mammalian members (BRD2, BRD3, BRD4, and BRDT) that regulate the expression of many...

The Bromodomain and Extra-Terminal Domain (BET) family of proteins is characterized by the presence of two tandem bromodomains and an extra-terminal domain. The mammalian BET family of proteins comprises BRD2, BRD3, BRD4, and BRDT, which are encoded ...

Nov 6, 2023 · The BET family of proteins contains the BRD proteins BRD2, BRD3, BRD4, and BRDT, which form subfamily V of the BRD family (Fig. 1). BET differs from other BRDs by having two highly conserved ...

Bromodomain protein 4 (Brd4) plays critical roles in development, cancer progression, and virus-host pathogenesis. To gain mechanistic insight into the various biological functions of Brd4, we performed a proteomic analysis to identify and characterize Brd4-associated cellular proteins.

Mar 23, 2016 · Specific inhibition of both Brd2 and Brd4 enhances insulin transcription, leading to increased insulin content. Inhibition of Brd2 alone increases fatty acid oxidation. Overlapping yet discrete roles for individual BET proteins in metabolic regulation suggest new isoform-selective BET inhibitors may be useful to treat insulin resistant/diabetic ...

Jul 21, 2017 · All three BET proteins BRD2, BRD3 and BRD4 exhibited distinct and dynamic patterns of protein expression over the course of differentiation without concomitant changes in mRNA levels, suggesting that BET proteins are regulated at the post-transcriptional level.

Mar 23, 2016 · Indeed, in the present paper, we report that individual BET proteins in the family (Brd2 and Brd4, but not Brd3) control related but distinct functions in the β-cell. We show that inhibition of BET bromodomain proteins actually increases production of insulin and improves pancreatic β-cell function.

Mar 18, 2025 · It shares the thienodiazepine scaffold with JQ1 and shows high affinity for the acetyl-lysine recognition pocket of BET bromodomains, including BRD4, BRD3, BRD2, and BRDT . BRD4, a primary target of RO6870810, is a universal gene transcription regulator . It has been linked to the upregulation of oncogenes like MYC, BCL2, CDK6, and FOSL1 [8, 9 ...

2 days ago · The bromodomain and extra-terminal family (BET) comprises the BRD2, BRD3, BRD4, and testis-specific BRDT proteins. As epigenetic readers, the two tandem bromodomains (BD1 and BD2) can recognize N-terminal acetylated lysine residues of histones and other proteins [1–4].The BET proteins fulfill a variety of biological functions, including regulating gene transcription, playing ...