Homologous Recombination and Human Health: The Roles of BRCA1…
BRCA1 and BRCA2 have distinct roles in HR. BRCA1 acts at an early HR step to promote end resection and at a later step to recruit PALB2 and, hence, promote BRCA2 chromatin …
BRCA1 and BRCA2: different roles in a common pathway of …
In the BRCA1–BRCA2-mediated HR pathway, BRCA1 functions upstream of BRCA2, the function of which is dependent on BRCA1. In mammalian cells, HR can also occur through an …
The role of BRCA1 in homologous recombination repair in response …
Unlike Brca1 mutants, Brca1/53BP1 double mutants are proficient for HR, and assemble RPA foci after DNA damage, arguing that the primary function of BRCA1 in DSB repair is to promote …
Homologous recombination and human health: the roles of BRCA1…
Apr 1, 2015 · The tumor suppressors BRCA1 and BRCA2, key players at different stages of HR, are frequently mutated in familial breast and ovarian cancers. Other HR proteins, including …
Genetic separation of Brca1 functions reveal mutation ... - Nature
Nov 24, 2023 · BRCA1 functions in homologous recombination (HR) by counteracting the 53BP1-Shieldin protein complex, thereby promoting DNA end resection 1, 2. Of equal significance, …
BRCA1: a key player at multiple stages of homologous recombination …
May 27, 2021 · In this review, we will summarize the underlying mechanisms of the recruitment BRCA1 to DSB and BRCA1’s functions at multiple stages of HR in DSB repair. We will also …
The antitumorigenic roles of BRCA1–BARD1 in DNA repair and
Feb 24, 2020 · In this Review, we focus on two key factors of the HR pathway in humans: breast cancer type 1 susceptibility protein (BRCA1) and its obligatory partner BRCA1-associated …
BRCA1 Directs the Repair Pathway to Homologous Recombination …
Jan 10, 2017 · BRCA1 promotes homologous recombination (HR) by activating DNA-end resection. By contrast, 53BP1 forms a barrier that inhibits DNA-end resection. Here, we show …
BRCA Pathway and Its Role in DNA Repair and Cancer Risk
Mar 21, 2025 · These tumor suppressors repair double-strand DNA breaks through homologous recombination (HR). BRCA1 acts as a scaffold, recruiting repair factors, while BRCA2 …
BRCA1 & BRCA2 methylation as a prognostic and predictive …
Dec 6, 2024 · BReast CAncer gene 1 (BRCA1) and BReast CAncer gene 2 (BRCA2) encode for tumor suppressor proteins which are critical regulators of the Homologous Recombination …