Mar 18, 2022 · To explore the regulatory mechanism of mitophagy, we cloned Bcl2/adenovirus E1B 19 kDa protein-interacting protein 3 (BNIP3), a common mitophagy receptor, from sea cucumber Apostichopus japonicus (AjBNIP3) and confirmed that AjBNIP3 was significantly induced and accumulated in mitochondria after V. splendidus infection and LPS exposure. At …

Mar 17, 2023 · BNIP3 deficiency increased the production of mitochondrial ROS, the NLRP3 inflammasome, and αSMA and TGFβ1 expression, indicating the protective role of BNIP3-mediated mitophagy in renal fibrosis.

Sep 12, 2019 · As a critical component of mitochondrial quality control, mitophagy targets damaged or dysfunctional mitochondria for prompt elimination, thereby preventing excessive reactive oxygen species...

Nov 19, 2022 · Here we show that BNIP3-dependent mitophagy protects genomic integrity in mouse ESCs. Deletion of Bnip3 increases cellular reactive oxygen species (ROS) and decreases ATP generation.

We provide evidence that Bnip3 functions as a mitochondrial sensor of oxidative stress where an increase in reactive oxygen species (ROS) induces the homodimerization and activation of Bnip3 via a conserved cysteine residue in the NH 2 terminus.

Mar 17, 2023 · These findings demonstrated that HIF1α-BNIP3-mediated mitophagy played a protective role against hypoxia-induced renal epithelial cell injury and renal fibrosis by reducing mitochondrial ROS and inhibiting activation of the NLRP3 inflammasome.

Mar 22, 2022 · BNIP3-dependent mitophagy can limit ROS generation and apoptosis in tumor cells by reducing dysfunctional mitochondria (Chourasia & Macleod, 2015; Sathiyaseelan et al., 2019). BNIP3 is also involved in the inhibition of nerve cell …

Mar 19, 2025 · Mitophagy is responsible for the scavenging of ROS and dysfunctional mitochondria and is considered a key therapeutic target for the treatment of OA. Tiopronin, a classic thiol antioxidant, has been widely studied for the treatment of various oxidative stress-related diseases. ... Moreover, tiopronin strongly activated the expression of Bnip3 ...

Jul 1, 2020 · Studies in multiple cells have further shown that activation of the BNIP3 gene promoter by upstream targets contributes to dysfunctional mitochondria and ROS generation. Li et al. have demonstrated that miR–182 inhibits Bnip3 expression to limit ROS production, suggesting the miR–182/Bnip3 axis plays a protective role in oxidative stress ...

Nov 15, 2024 · In summary, our data demonstrated a renoprotective mechanism of αKlotho by promoting BNIP3-mediated mitophagy in CI-AKI. αKlotho prevented CM-induced tubular cells apoptosis and tissue damage by decreasing mitochondria damage and mitochondrial ROS generation via FoxO3-BNIP3-mitophagy axis.