Dec 20, 2021 · BNIP3L promotes mitophagy either via recruiting autophagosomes to target mitochondria or enhancing the formation of autophagosomes. BNIP3L-mediated mitophagy is …

Apr 11, 2022 · Microtubule-associated protein 1 light chain 3 (LC3) interacts with Bnip3 protein to selectively remove endoplasmic reticulum and mitochondria via autophagy. J Biol Chem. …

The mitochondria-localized BNIP3 interacts with the autophagosome-localized LC3, suggesting that BNIP3, similar to NIX, functions as a LC3-binding receptor on mitochondria. Although NIX …

Mitochondria‐localized BNIP3 interacted with LC3 in the neuronal mitophagy in stroke models. Protein–protein interactions between NIX and LC3, and BNIP3 and LC3 were confirmed by …

Jun 1, 2012 · Results: Bnip3 homodimerization and binding to LC3 induces selective autophagy of mitochondria and ER. Conclusion: Bnip3 plays a direct and selective role in autophagy. …

Aug 12, 2024 · Fortunately, ligustilide (LIG) was found to have the ability to reverse the oxidative stress-induced downregulation of BNIP3 and enhance mitophagy through BNIP3-LC3 …

Jun 1, 2012 · We found that Bnip3 enhanced autophagy in cells from both sites. We also discovered that Bnip3 induced removal of both ER (ERphagy) and mitochondria (mitophagy) …

Despite recent advances in our understanding of its regulation by phosphorylation and dimerization, there remain numerous questions on how BNIP3L/NIX tightly balances between …

Feb 8, 2021 · Here we show that BNIP3 is required for GCG-induced mitophagy in the liver through interaction with processed LC3B; an interaction that is also necessary to localize …

Second, the autophagy protein LC3 binds to the LIR motif in the Bnip3 homodimer to induce removal of mitochondria and ER. Third, disrupting the interaction between Bnip3 and LC3 …