Role of bone morphogenetic protein-2 in osteogenic …
In the present study, forced expression of BMP-2 in the BMSCs not only induced ALP activity and promoted the formation of calcium nodules, but also improved the adherence of BMSCs. BMP …
BMP-2 Long-Term Stimulation of Human Pre-Osteoblasts Induces …
Osteogenesis was promoted by 1 µg/mL and 2 µg/mL BMP-2 (in total 200 ng and 400 ng) for up to 28 days, as indicated by the increased ALP activity and enhanced gene expression levels of …
BMP2 induces hMSC osteogenesis and matrix remodeling - PMC
Bone morphogenetic protein 2 (BMP2) serves an important role in inducing the osteogenic differentiation of mesenchymal stem cells (MSCs). Regulating the bone marrow matrix …
Enhancing Cell Proliferation and Osteogenic Differentiation of
Oct 2, 2017 · Bone morphogenetic protein-2 (BMP-2), a key factor in inducing osteogenesis and promoting bone regeneration, has been widely used in various clinical therapeutic trials. In this …
Engineering immunomodulatory and osteoinductive implant …
Jan 10, 2022 · Here, a dual-effect coating with immobilized immunomodulatory metal ions (e.g., Zn 2+) and osteoinductive growth factors (e.g., BMP-2 peptide) is designed via mussel …
Bone Morphogenetic Protein-2 in Development and Bone …
Sep 13, 2020 · BMP-2 has important roles during embryonic development, as well as bone remodeling and homeostasis in adulthood. Some of its specific functions include digit …
Bone Morphogenetic Protein-2 and Osteopontin Gene Expression …
Jun 11, 2020 · The mRNA expression of bone morphogenetic protein-2 and -4 (BMP-2, BMP-4), osteopontin (OPN), osteonectin (ON), and osteoprotegerin (OPG) in EAT was determined by …
Role of bone morphogenetic protein-2 in osteogenic ... - PubMed
Following forced expression of BMP‑2 in the BMSCs, the levels of osteogenic genes, including osteopontin (OPN), osteocalcin (OC) and collagen type I (Col‑Ⅰ), were detected and the …
TGFbeta and BMP-2 activation of the OPN promoter: roles of
Jan 1, 2001 · Deletion of the first 9 bases in the Smad-binding region substantially reduced BMP-2-mediated activation of the promoter. These results strongly suggest that both the Hox- and …
RUNX2, ALP, BMP-2, Col-1A1, OCN, and OPN gene
RUNX2, ALP, BMP-2, Col-1A1, OCN, and OPN gene transcription determined by real-time quantitative polymerase chain reaction analysis. Target gene expression levels were …
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