Apr 3, 2013 · To determine whether Bmal1 influences cellular invasiveness, we overexpressed Bmal1 in human A549 lung cancer cells (Fig. 1A). This resulted in a dramatic reduction in cellular invasiveness, as analyzed on Matrigel-coated polycarbonate filters (Fig. 1B).

Several studies have shown that brain and muscle aryl hydrocarbon receptor nuclear translocator-like 1 (BMAL1), an important molecule for maintaining circadian rhythms, inhibits the growth and metastasis of tumor cells in several types of cancer, including lung, colon, and breast cancer.

For this, we transfected a mixture of four siRNA oligos targeting different sequences of human BMAL1 gene to knock down the expression of BMAL1 in NHLFs, HPL1D and A549 cells, and the effects of BMAL1 knockdown on the TGF-β1-induced activities were investigated.

To determine whether Bmal1 influences cellular invasiveness, we overexpressed Bmal1 in human A549 lung cancer cells (Fig. 1A). This resulted in a dramatic reduction in cellular invasiveness, as...

Apr 3, 2013 · Bmal1 suppresses A549 lung cancer cell invasion. (A) Human A549 lung cancer cells were transfected with the empty (control) or Bmal1-expressing pCMV-SPORT6 vectors. Where indicated,...

Nov 21, 2020 · Human serum treatment increases Bmal1 transcription in A549 cells. human osteosarcoma u2os cell line cells, HUVECs and A549 cells were incubated with human serum for 26 h and the mRNA expression of Bmal1 (a), Cry1 (b) and Per1 (c) was analysed by real-time quantitative RT-PCR.

Download scientific diagram | Effect of BMAL1 knockdown on TGF-β1-induced EMT of A549 human lung carcinoma cells. a A549 cells were transiently transfected with siBMAL1 or siCtrl for 72 h.

To determine whether Bmal1 influences cellular invasiveness, we overexpressed Bmal1 in human A549 lung cancer cells (Fig. 1A). This resulted in a dramatic reduction in cellular invasiveness, as analyzed on Matrigel-coated polycarbonate filters (Fig. 1B).

Oct 18, 2023 · Intriguingly, we found L-Theanine can significantly decrease the expression of cancer stemness-related markers in DDP-resistant lung cancer cells (A549/DDP, NCI-H446/DDP) but not in lung cancer cells without DDP-resistance (A549 and NCI-H446).

Jan 12, 2016 · For this, we transfected a mixture of four siRNA oligos targeting different sequences of human BMAL1 gene to knock down the expression of BMAL1 in NHLFs, HPL1D and A549 cells, and the effects of BMAL1 knockdown on the TGF-β1 …