BID is a pro-apoptotic Bcl-2 protein containing only the BH3 domain. In response to apoptotic signaling, BID interacts with another Bcl-2 family protein, Bax, leading to the insertion of Bax …

BH3-only BCL-2 family proteins are effectors of canonical mitochondrial apoptosis. They discharge their pro-apoptotic functions through BH1-3 pro-apoptotic proteins such as BAX and …

BH3-only proteins play a crucial role in the killing of tumour cells by anti-cancer agents (see Strasser et al., 2011). Efficient killing of MYC-driven lymphomas in mice by DNA-damaging …

A BH3 protein is defined as a type of protein that contains BH3 motifs which bind and regulate Bcl-2 homologs, playing a crucial role in cellular responses to stress-induced cues and cell …

Apr 1, 2011 · BH3-only proteins monitor many cellular processes and transmit both intrinsic and extrinsic death signals to the multi-region Bcl-2 family proteins at the MOM. BH3-only proteins …

Jan 1, 2017 · BH3-only proteins are proapoptotic members of the broader Bcl-2 family, which promote cell death by directly or indirectly activating Bax and Bak. The expression of BH3-only …

Within the BCL-2 family exists a subclass of pro-apoptotic members termed the BH3-only proteins, which directly and/or indirectly functionally regulate the remaining anti- and pro …

4 days ago · The BH3-only proteins can bind with very high affinity to the pro-survival BCL-2 proteins, thereby unleashing the effectors of apoptosis, BAX and BAK.

Jul 30, 2009 · The BH3-only proteins activate apoptosis by binding and neutralizing the pro-survival proteins, allowing Bax/Bak to homo-oligomerize and permeabilize the mitochondria.

Jul 30, 2009 · BH3-only BCL-2 family proteins are effectors of canonical mitochondrial apoptosis. They discharge their pro-apoptotic functions through BH1–3 pro-apoptotic proteins such as …