The BH3 interacting-domain death agonist, or BID, gene is a pro- apoptotic member of the Bcl-2 protein family. [5] Bcl-2 family members share one or more of the four characteristic domains of homology entitled the Bcl-2 homology (BH) domains (named BH1, BH2, BH3 and BH4), and can form hetero- or homodimers.

The BH3-only subset of the Bcl-2 family of proteins contain only a single BH3-domain. The BH3-only members play a key role in promoting apoptosis. The BH3-only family members are Bim, Bid, BAD and others.

Mar 30, 2025 · BID (BH3 Interacting Domain Death Agonist) is a Protein Coding gene. Diseases associated with BID include Colon Adenocarcinoma and Gastric Adenocarcinoma. Among its related pathways are TNFR1 Pathway and Intrinsic Pathway for Apoptosis.

BH3-only BCL-2 family proteins are effectors of canonical mitochondrial apoptosis. They discharge their pro-apoptotic functions through BH1-3 pro-apoptotic proteins such as BAX and BAK, while their activity is suppressed by BH1-4 anti-apoptotic BCL-2 family members.

Feb 8, 2025 · This gene encodes a death agonist that heterodimerizes with either agonist BAX or antagonist BCL2, and thus regulate apoptosis. The encoded protein is a member of the BCL-2 family of cell death regulators.

May 24, 2022 · This review aims to clarify the key features of BH3 motifs and the structural determinants of currently known BH3-mediated interactions and their implication for structural studies and identification of new binding motifs. BH3 motifs are found both inside and outside of the BCL2 protein family.

We present evidence in this study that bbc3 is a strongly proapoptotic BH3-only gene that is subject to transcriptional regulation by multiple cell death-signaling pathways.

Within the BCL-2 family exists a subclass of pro-apoptotic members termed the BH3-only proteins, which directly and/or indirectly functionally regulate the remaining anti- and pro-apoptotic BCL-2 proteins to compromise mitochondria and engage apoptosis.

Feb 8, 2025 · This gene encodes a death agonist that heterodimerizes with either agonist BAX or antagonist BCL2, and thus regulate apoptosis. The encoded protein is a member of the BCL-2 family of cell death regulators.

A BH3 protein is defined as a type of protein that contains BH3 motifs which bind and regulate Bcl-2 homologs, playing a crucial role in cellular responses to stress-induced cues and cell death regulation in the field of Neuroscience.