Tropomyosin receptor kinase B (TrkB), [5] [6] [7] also known as tyrosine receptor kinase B, or BDNF/NT-3 growth factors receptor or neurotrophic tyrosine kinase, receptor, type 2 is a protein that in humans is encoded by the NTRK2 gene. [8]

Brain-derived neurotrophic factor (BDNF)/tropomyosin-related kinase receptor type B (BDNF/TrkB) signaling supports neuronal survival, plasticity, differentiation, and growth via activation of several functional downstream cascades.

Jan 1, 2024 · The different TrkB isoforms, including TrkB full-length, TrkB.T1, TrkB.shc, and TrkB.tk, exhibit distinct structural and functional properties, contributing to diverse cellular processes and modulations of BDNF signaling in the central nervous system.

In the present work, we review the relationship between the BDNF/TrkB pathway and RGC survival in the developing, healthy, and glaucomatous retina. A common theme emerges of temporal and spatial alterations in the BDNF/TrkB pathway throughout the visual system in response to RGC injury.

Jan 1, 2024 · The BDNF/TrkB signaling pathway is crucial for neuronal survival, structural changes, and plasticity. BDNF acts as an axonal growth and extension factor, a pro-survival factor, and a synaptic modulator in the CNS.

Signaling via brain-derived neurotrophic factor (BDNF) and its receptor, tropomycin receptor kinase B (TrkB) plays a key role in the pathophysiology of depression and in the therapeutic mechanisms of antidepressants.

The seizure-induced expression of BDNF and parallel enhancement of TrkB activation advanced BDNF/TrkB signaling as one candidate molecular mechanism by which seizures could promote epileptogenesis. To investigate this possibility, initial work utilized the kindling model.

Jan 17, 2020 · The expression of BDNF/TrkB in the substantia nigra is significantly reduced in Parkinson's Disease (PD) patients. This review summarizes recent progress in the understanding of the cellular and molecular roles of BNDF/TrkB signaling and …

Mar 2, 2024 · Antidepressant drugs act as allosteric potentiators of brain-derived neurotrophic factor (BDNF) signaling through binding to TrkB. Cholesterol modulates the structure and function of TrkB. Agonist TrkB antibodies are being developed for neurodegenerative disorders.

Jun 2, 2022 · BDNF acts through its full-length BDNF receptor tyrosine kinase B (TrkB) to trigger a pro-plasticity effect. In contrast, the truncated isoform of the BDNF receptor (TrkB.t1) triggers an anti-plasticity effect.