BDNF can promote protective pathways and inhibit damaging pathways in the NSCs and NPCs that contribute to the brain's neurogenic response by enhancing cell survival. This becomes …

Brain-derived neurotrophic factor (BDNF) plays an important role in neuronal survival and growth, serves as a neurotransmitter modulator, and participates in neuronal plasticity, which is …

Here, we report a brief overview on brain neurotrophic factor (BDNF)–tropomyosin receptor kinase (Trk) pathway, describing its numerous roles in the maintenance of central nervous …

BDNF synthesis and maturation is a multistage sequence of intra- and extracellular processes. In the intracellular pathway, the pre-pro-BDNF precursor sequence is produced in the …

Jan 1, 2024 · The BDNF/TrkB signaling pathway is crucial for neuronal survival, structural changes, and plasticity. BDNF acts as an axonal growth and extension factor, a pro-survival …

Brain-derived neurotrophic factor (BDNF) and its receptor, TrkB, are broadly expressed in the developing and adult mammalian brain. BDNF / TrkB-stimulated intracellular signaling is …

Jan 1, 2024 · As one of the most prevalent neurotrophic factors in the central nervous system (CNS), brain-derived neurotrophic factor (BDNF) plays a significant role in CNS injury by …

Jan 29, 2019 · These functions are carried out through three pathways: mitogen-activated protein kinase (MAPK), phospholipase CG (PLC/PLCG), and phosphatidylinositol 3-kinase (PI3K). …

BDNF affects neurons positively or negatively through various intracellular signaling pathways triggered by activation of TrkB or p75. From a clinical standpoint, roles of BDNF have been …

Brain-derived neurotrophic factor (BDNF) is a neurotrophin essential for growth, differentiation, plasticity, and survival of neurons. BDNF is also required for processes such as energy …