BDNF-TrkB and proBDNF-p75NTR/Sortilin Signaling Pathways are ... - PubMed
Results: proBDNF induced mitochondrial apoptosis of SGCs and neurons by modulating BDNF-TrkB and proBDNF-p75NTR/sortilin signaling pathways. In addition, neuroprotection was …
BDNF-TrkB/proBDNF-p75 - Nature
Oct 26, 2023 · Rapid intravenous administration of lipid emulsion (LE) could be used to treat local anaesthetic toxicity. This study aimed to investigate the mechanism by which the BDNF …
Up-regulation of proBDNF/p75 - Science | AAAS
Jan 19, 2022 · The present study shows that brain-derived neurotrophic factor precursor (proBDNF) and its high-affinity pan-75 neurotrophin receptor (p75 NTR) are highly expressed …
p75 neurotrophin receptor and pro-BDNF promote cell survival …
Jun 7, 2016 · Brain-Derived Neurotrophic Factor (BDNF), a member of neurotrophin family has been described to play an important role in development and progression of several cancers, …
A network map of BDNF/TRKB and BDNF/p75NTR signaling system
TrkB is expressed in the central and peripheral nervous system (Allen et al. 1994). Like other neurotrophins, BDNF also binds to nerve growth factor receptor (NGFR), also known as p75 …
In vivo functions of p75 - PubMed Central (PMC)
p75 NTR is a driver of disease pathogenesis in neurological, metabolic, and fibrotic diseases. p75 NTR is highly pleiotropic interacting with multiple ligands, co-receptors, and signaling …
Activation of p75NTR by proBDNF facilitates hippocampal long-term ...
Pro- and mature brain-derived neurotrophic factor (BDNF) activate two distinct receptors: p75 neurotrophin receptor (p75(NTR)) and TrkB. Mature BDNF facilitates hippocampal synaptic …
Dysregulation of proBDNF/p75 NTR and BDNF/TrkB Signaling in …
BDNF activates tropomyosin receptor kinase B (TrkB) receptor results in promoting neuronal survival, synaptic plasticity, and neuronal growth. However, the proBDNF activates p75 …
Differential contribution of TrkB and p75NTR to BDNF-dependent …
Dec 22, 2023 · However, higher concentrations of BDNF that can bind the p75 neurotrophin receptor (p75 NTR) potentiate TrkB-dependent self-renewal and proliferation and promote …
ProBDNF Induces Neuronal Apoptosis via Activation of a …
Jun 1, 2005 · Brain-derived neurotrophic factor (BDNF) is best characterized for critical roles in neuronal survival, differentiation, and synaptic modulation mediated by the TrkB receptor …
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