Here, we address the developmental cell death mechanisms of brain-derived neurotrophic factor (BDNF)-dependent dorsal root ganglion (DRG) neurons in vitro, comparing and contrast them …

Jan 14, 2020 · Here we demonstrate a critical contribution of DRG macrophages, but not those at the nerve injury site, to both the initiation and maintenance of the mechanical hypersensitivity …

Sep 30, 2011 · However, the precise role of BDNF and trkB receptor in the primary sensory neurons of dorsal root ganglia (DRG) during inflammation remains to be clarified. The aim of …

Nov 1, 2018 · We examined nerve growth factor (NGF) and brain-derived neurotrophic factor (BDNF) expression in the DRGs of SNI model mice. NGF and BDNF levels increased in the …

DRGs represent an important peripheral site of plasticity driving neuropathic pain. Changes in ion channel/receptor function are critical to nociceptor hyperexcitability. Peripheral BDNF-TrkB …

Jan 21, 2021 · Using a well-established in vitro culture model of dorsal root ganglion (DRG), we have examined degeneration mechanisms triggered on BDNF withdrawal in sensory neurons. …

Here, we demonstrate that BDNF exerts contrasting influences on peripheral myelination: enhancing myelination of NGF-dependent DRG neurons but inhibiting myelination of BDNF …

Jul 11, 2014 · Brain-derived neurotrophic factor (BDNF) is a member of the neurotrophic family and plays important roles in survival, differentiation, and synaptic plasticity of neurons. 2 BDNF …

Dec 9, 2024 · Brain-derived neurotrophic factor (BDNF), which is primarily expressed in the brain and nervous tissues, is the most abundant neurotrophic factor in the adult brain. BDNF serves …

In this study, we examined the functional role of BDNF-AS in regulating local anesthetic-induced neurotoxicity in dorsal root ganglion (DRG) neurons. Methods: Neonatal mouse DRG neurons …