May 14, 2010 · Spleen tyrosine kinase (SYK) is a non-receptor tyrosine kinase that has long been thought to exclusively mediate signalling by receptors of the adaptive immune response (B...

In this study, we first demonstrate that CD40 ligation modifies BCR-induced B cell activation by promoting activation of Syk and formation of signaling complex consisting of Syk, Vav-2, Btk, BLNK, and PLC-γ2, thus leading to activation of p38 MAPK, ERK, Akt, and NF-κB.

In the PLC-γ2 pathway, the B cell linker (BLNK) is a key adaptor protein that recruits Syk and Btk. After BCR antigen stimulation, Y204, an evolutionarily conserved non-ITAM tyrosine residue, near the ITAM of Igα recruits BLNK through SH2 domain binding to phosphorylated Igα.

Mar 29, 2021 · Enhanced BCR signaling and autoreactive B cells have been implicated in the pathogenesis of autoimmune diseases, B lineage leukemias and lymphomas. Molecular mechanisms underpinning the malignant...

In this report, we attempted to characterize the signaling synergy between BCR- and CD40-mediated pathways during B cell activation. We found that spleen tyrosine kinase (Syk) is involved in CD40 signaling, and is synergistically activated …

Feb 15, 2008 · Ligand-induced BCR signaling induces receptor oligomerization, Igalpha/beta immunoreceptor tyrosine-based activation motif (ITAM) phosphorylation, and activation of the spleen tyrosine kinase (SYK), which initiates downstream events and amplifies the …

May 15, 2015 · In this study, we show that Syk-deficient primary mouse B cells have a severe defect in BCR-induced activation, proliferation, and survival. Furthermore, we demonstrate that Syk is required for both T-dependent and T-independent Ab responses, and that this requirement is B cell intrinsic.

Spleen tyrosine kinase (Syk) is a critical component of this signaling machinery. Studies in “knockout” mice and cell lines indicate that Syk is essential for most of the biochemical responses to BCR engagement [7 – 10].

In this study, we show that Syk-deficient primary mouse B cells have a severe defect in BCR-induced activation, proliferation, and survival. Furthermore, we demonstrate that Syk is required for both T-dependent and T-independent Ab responses, and that this requirement is …

Dec 18, 2008 · We now report that Syk is constitutively phosphorylated on the activating Y352 residue in chronic lymphocytic leukemia (CLL) B cells. To examine the effects of constitutive Syk activity on...