Jun 6, 2019 · Th17 cells provide a protective immunity against extracellular bacterial and fungal pathogens. Kotov et al. identify and characterize a mechanism by which BCOR promotes Th17 formation after Streptococcus pyogenes infection by repressing genes that inhibit the …

Apr 15, 2010 · The transcriptional repressor protein BCL6 regulates T cell differentiation by repressing Th2 responses and promoting follicular Th cell responses. However, little is known about the role of BCL6 in Th17 responses. We found that memory T cells from BCL6-deficient mice had increased IL-17 production. …

Apr 1, 2009 · Further, we have found that BCL6 is significantly up-regulated in T cells stimulated under Th17 conditions, indicating a unique requirement for BCL6 in Th17 differentiation. These data show a novel, critical role for BCL6 in promoting Th17 responses.

Apr 30, 2024 · DC-specific loss of Bcl6 causes defects in Th17 cell priming in the colon of mice infected with C. rodentium. In addition to their role in driving GC reactions in the spleen, Notch2-dependent cDC2 have been shown to support Th17-dependent immunity towards C. …

Sep 3, 2021 · We identified the transcription factor Bcl6 in Th17 cells to promote interactions with meningeal B cells, isotype-switching, and B cell-supporting chemokines.

Jun 3, 2019 · Using T cell-specific loss-of-function experiments, we find that two components of the Polycomb repressive complex 1.1 (PRC1.1), BCL6 corepressor (BCOR) and KDM2B, which helps target the complex to unmethylated CpG DNA islands, are required for optimal Th17 cell formation in mice after Streptococcus pyogenes infection.

In Th cells, Bcl6 was reported to inhibit Th1, Th2, and Th17 development by suppressing Tbet, GATA3, and RORγt expression and activities (29, 41, 47). Meanwhile, it was reported that Bcl6 represses GATA3 expression in Treg cells and thus prevents Treg cells from acquiring Th2 effector-like characteristics.

Apr 15, 2010 · The transcriptional repressor protein BCL6 regulates T cell differentiation by repressing Th2 responses and promoting follicular Th cell responses. However, little is known about the role of BCL6 in Th17 responses. We found that memory T cells from BCL6-deficient mice had increased IL-17 production.

Feb 23, 2016 · Here, we defined Bcl6 target genes in Tfh cells by analyzing genome-wide Bcl6 occupancy together with transcriptome profiling. With consensus sequences being different from those in Th9, B cells, and macrophages, Bcl6 binding in Tfh cell was closely associated with a decrease in 5-hydroxymethylcytosine (5hmC).

Apr 30, 2024 · DC-targeted Bcl6-deficient mice induced fewer T follicular helper cells despite a profound impact on T follicular regulatory cells in response to immunization and mounted diminished Th17...