Sep 24, 2012 · T follicular helper cells (Tfh cells) play a pivotal role in germinal center reactions, which require B cell lymphoma 6 (Bcl6) transcription factor. To analyze their relationships with other effector T cell lineages and their stability in vivo, we developed and analyzed a new Bcl6 reporter mouse alo …

Jul 26, 2023 · To test whether TCIP1 derepresses BCL6-regulated gene expression using endogenous levels of BCL6 and BRD4, we designed a BCL6 reporter from known BCL6-binding sites at promoters of cell death...

Nov 18, 2020 · Binding of the small molecule BI-3802 to the oncogenic transcription factor B cell lymphoma 6 (BCL6) induces polymerization of BCL6, leading to its ubiquitination by SIAH1 and proteasomal...

Jun 24, 2011 · By using a Bcl6 reporter mouse strain, we found that antigen-engaged B cells upregulated Bcl6 before clustering in GCs. Two-photon microscopic analysis indicated that Bcl6 upregulation in pre-GC B cells contributed to sustaining their interactions with helper T cells and was required for their entry to GC clusters.

In this paper, we identify a set of miRNAs whose expression is repressed by BCL6, leading to a positive regulation of their target genes. In particular, we characterize the direct repression of miR-155 and miR-361 by BCL6 and investigate the downstream consequences of these interactions.

To analyze their relationships with other effector T cell lineages and their stability in vivo, we developed and analyzed a new Bcl6 reporter mouse alone or together with other lineage...

Jun 24, 2011 · The present study describes the tracking of Bcl6 protein expression in individual Ag-engaged B cells and helper T cells during Ab responses, which was facilitated by the Bcl6 reporter mouse whose Bcl6 gene locus encodes YFP-Bcl6 fusion protein.

Jun 22, 2020 · In this study, we took a first-principles-based approach to define and test hypothetical models of how Bcl-6 may control T FH biology. One proposed model of T FH differentiation is that T FH...

Here, we designed small-molecule inhibitors that display higher affinity for BCL6 than its endogenous corepressor ligands to evaluate their therapeutic efficacy for targeting ABC-DLBCL.

Feb 15, 2006 · Luciferase reporter assays revealed that the BCL6 intron 1 can confer p53-dependent transcriptional activation through the p53RE. BCL6 mRNA levels increased after chemotherapy and/or γ-irradiation in human peripheral-blood lymphocytes (PBLs) and cell lines but not in murine tissues.