Feb 1, 2022 · A positive BCL-6 test result points to the presence of inflammation in the uterine lining. Researchers think that this inflammation affects reproductive outcomes and leads to infertility (difficulty conceiving spontaneously after 12 months). The most common association is with endometriosis.

We sought to confirm the positive predictive value (PPV) of endometrial BCL-6 overexpression in identifying endometriosis in women with unexplained infertility.

Aug 3, 2023 · The neoplastic cells are positive for CD20, denoting a B cell origin. Following the Hans algorithm, a DLBCL that is negative for CD10 and positive for both BCL6 and MUM1 is nongerminal center subtype.

BCL6+, MUM1–, MYC+, BCL2– Probably Burkitt lymphoma, particularly if IG/MYC identified. Confirm with morphology and clinical. HGBCL, not otherwise specified HGBCL vs Burkitt lymphoma Any other phenotype Positive for BCL2 and/or BCL6 rearrangements High-grade B-cell lymphoma, with MYC and BCL2 and/or BCL6 rearrangements COO IHC (CD10, BCL6 ...

Jul 24, 2019 · ReceptivaDX finds pathways for women with elevated endometrial BCL6 expression, failed IVF history & recurrent pregnancy loss to improve treatment outcome.

The protein encoded by the BCL6 gene is a zinc finger transcription factor that has three evolutionarily conserved domains. BCL6 contains a (1) N-terminal BTB/POZ domain (Broad-complex, Tramtrack and Brick-a-brac/Pox virus and Zinc finger family domain), (2) a central RN2 region, and (3) another zinc finger at the C-terminal end. [6]

Bcl-6 was positive in 13.6% (6 of 44) of cases (11.1% of mantle cell lymphoma and 40% of diffuse large B-cell lymphoma) and its positivity implies a better disease course. Bcl-2 and Bcl-6 can be used as prognostic marker in NHL.

Jun 24, 2022 · A positive BCL6 test indicates that you may have inflammation on the uterine lining, most often associated with endometriosis and that can affect your reproductive outcome. Without treatment, you can get pregnant with a positive BCL6 result using IVF, but the chances are low, about 12% on the next transfer according to studies.

Positive BCL6 results treated with either laparoscopy or GnRH agonist showed improved outcomes (79% pregnancy rate and 64% LBR or on-going pregnancies). BCL6 positive patients treated with Lupron showed the highest pregnancy rates (81%) and …

May 31, 2024 · What is BCL6 and the link to endometriosis? BCL6 is the primary biomarker in the ReceptivaDx test for detection of endometriosis. This protein is an “oncogene” associated with lymphoma and involved with inflammation.