Bcl-6 (B-cell lymphoma 6) is a protein that in humans is encoded by the BCL6 gene. BCL6 is a master transcription factor for regulation of T follicular helper cells (T FH cells) proliferation. [5] BCL6 has three evolutionary conserved structural domains. [6]

Aug 3, 2023 · BCL6 is a transcription factor located at 3q27 and is required for germinal center B cells formation and follicular helper T cells (TFH) differentiation

BCL6 encodes a zinc finger transcription repressor that is frequently translocated in diffuse large B-cell lymphomas (DLBCL; ref. 1). A master regulator of humoral immunity, the BCL6 protein plays a critical role in the initiation and maintenance of the germinal centers (GC).

Nov 19, 2010 · BCL6 proto-oncogene is one of the markers for germinal center origin in DLBCL and encodes a transcriptional repressor factor. Mutation or translocation affecting this proto-oncogene has been implicated in the pathogenesis of certain subtypes of DLBCL.

Targeting the BCL6 BTB domain corepressor interface could thus specifically suppress B-cell survival without inducing acute or chronic inflammatory effects that instead would be expected to occur with the complete loss of BCL6.

B cell lymphoma 6 (BCL6) is a conserved multi-domain protein that functions principally as a transcriptional repressor. This protein regulates many pivotal aspects of immune cell development and function.

Dec 2, 2022 · B-cell lymphoma 6 (BCL6) is a protooncogene in adult and pediatric cancers, first identified in diffuse large B-cell lymphoma (DLBCL) where it acts as a repressor of the tumor suppressor TP53, conferring survival, protection, and maintenance of lymphoma cells.

B cell lymphoma 6 (BCL6) is a transcriptional repressor critical for the development and maintenance of germinal centers (GCs), which are required for generation of an effective humoral immune response.

Dec 2, 2022 · BCL6 encodes a zinc finger transcription repressor that is frequently translocated in diffuse large B-cell lymphomas (DLBCL; ref. 1). A master regulator of humoral immunity, the BCL6 protein plays a critical role in the initiation and maintenance of the germinal centers (GC).

BCL6 is a transcription factor that has essential B-cell and T-cell roles in normal antibody responses. It is involved in chromosomal translocations in diffuse large B-cell lymphoma (DBCL; including primary mediastinal B-cell lymphoma) and nodular lymphocyte predominant Hodgkin lymphoma, and is expr …