Aug 3, 2023 · BCL6 is a transcription factor located at 3q27 and is required for germinal center B cells formation and follicular helper T cells (TFH) differentiation

Bcl-6 was positive in 13.6% (6 of 44) of cases (11.1% of mantle cell lymphoma and 40% of diffuse large B-cell lymphoma) and its positivity implies a better disease course. Bcl-2 and Bcl-6 can …

Typical IHC results of DLBCL NOS are characterized by large, atypical CD3-negative and CD20-positive lymphocytes with a Ki-67 labeling index greater than 80%. Further, the cell of origin …

Bcl-6 is a proto-oncogene that encodes a Kruppel-type zinc-finger protein of 95 kD and shares homology with other transcription factors. Bcl-6 protein is mainly expressed in normal germinal …

Nov 19, 2010 · Studies using both gene expression profiling and immunohistochemistry (IHC) have demonstrated that BCL6 gene or Bcl-6 protein expression alone or in combination with …

Gene expression profiling of diffuse large B-cell lymphoma (DLBCL) has revealed biologically and prognostically distinct subgroups: germinal center B-cell-like (GCB), activated B-cell-like (ABC) …

1 day ago · Monoclonal Antibody for studying BCL6. Validated for IHC, IHC. Available in 2 sizes. Highly specific and rigorously validated in-house, BCL6 (E5I8I) Rabbit Monoclonal Antibody …

Bcl-6 is a master transcription factor for the regulation of T follicular helper cells (T FH cells). Bcl-6 is expressed when the cytokines Il-6 and/or Il-21 are recognized; these cytokines can be …

Nov 11, 2022 · Here, we identify B cell lymphoma 6 (BCL6) as a lynchpin in KRAS -driven lung cancer. BCL6 expression was increased upon KRAS activation in lung tumor tissue in mice …

BCL-6 protein is a transcription factor expressed by follicle center B cells and other cells of the follicle center. It is useful in the classification of lymphomas. This test does not include …