Bcl-2, encoded in humans by the BCL2 gene, is the founding member of the Bcl-2 family of regulator proteins. BCL2 blocks programmed cell death (apoptosis) [5] while other BCL2 family members can either inhibit or induce it. [6][7] It was the …

The Bcl-2 family (TC# 1.A.21) consists of a number of evolutionarily-conserved proteins that share Bcl-2 homology (BH) domains. The Bcl-2 family is most notable for their regulation of apoptosis, a form of programmed cell death, at the mitochondrion. [2]

Members of the B-cell lymphoma 2 (BCL-2) protein family have pro- or anti-apoptotic activities and have been studied intensively over the past decade for their importance in regulating apoptosis, tumorigenesis, and cellular responses to anticancer therapy.

BCL-2 family proteins have either pro- or anti-apoptotic activities that are crucial for the regulation of apoptosis, tumorigenesis and cellular responses to anti-cancer therapy.

The landmark discovery of the BCL-2 gene and then its function marked the identification of inhibition of apoptotic cell death as a crucial novel mechanism driving cancer development and launched the quest to discover the molecular control of apoptosis. This work culminated in the generation of spec …

Jul 12, 2023 · In this Review, we revisit the most important advances in the field and integrate them into a new structure–function-based classification of the BCL-2 family members that intends to provide a...

Pro- and antiapoptotic BCL-2 family proteins have critical roles in normal cell physiology. These proteins have a characteristic shape and may harbor a common biochemical function not yet discovered. WHAT ARE BCL-2 FAMILY PROTEINS AND HOW DO THEY WORK?

Here, we review how the Bcl-2 family of proteins mechanistically regulate mitochondrial Ca 2+ homeostasis and how this regulation orchestrates cell death/survival decisions as well as the non-apoptotic process of cell migration. Keywords: Bcl-2 proteins, mitochondrial calcium homeostasis, VDAC, IP 3 R, apoptosis, cell migration 1. Introduction

Acquired resistance to cell death is a hallmark of cancer. The BCL-2 protein family members play important roles in controlling apoptotic cell death.

Aug 28, 1998 · Bcl-2 and related cytoplasmic proteins are key regulators of apoptosis, the cell suicide program critical for development, tissue homeostasis, and protection against pathogens. Those most similar to Bcl-2 promote cell survival by inhibiting adapters needed for activation of the proteases (caspases) that dismantle the cell.