The Bcl-2 family (TC# 1.A.21) consists of a number of evolutionarily-conserved proteins that share Bcl-2 homology (BH) domains. The Bcl-2 family is most notable for their regulation of …

Nov 17, 2017 · We highlight the core mechanisms of BCL-2 family regulation of MOMP with an emphasis on how the interactions between the BCL-2 family proteins govern cell fate.

4 days ago · Structured family members include those with pro-survival function, e.g., BCL-2, BCL-XL, MCL-1, and viral pro-survival homologs, the pro-apoptotic effectors BAX, BAK, and …

The Bcl-2 family is defined by homology shared within four conserved regions in Bcl-2, termed BCL-2 homology (BH) domains, and is grouped into three subfamilies depending on their …

Bcl-2, encoded in humans by the BCL2 gene, is the founding member of the Bcl-2 family of regulator proteins. BCL2 blocks programmed cell death [5] while other BCL2 family members …

The BCL-2 family has four main functions: inhibitory effects (BCL-2, BCL-Xl, BCL-W, BCL2-A1, and MCL-1), activation (BIM and PUMA), effector (BAX and BAK), and sensitization (NOXA). …

Nov 11, 2024 · B cell CLL/lymphoma-2 (BCL-2) and its relatives comprise the BCL-2 family of proteins, which were originally characterized with respect to their roles in controlling outer …

The B cell CLL/lymphoma-2 (BCL-2) family of proteins control the mitochondrial pathway of apoptosis, also known as intrinsic apoptosis. Direct binding between members of the BCL-2 …

Feb 21, 2019 · BCL-2 family members play an integral role in apoptosis, but also contribute to many other cellular functions. Isoforms of almost all of the BCL-2 family members have been …

Aug 28, 1998 · The CED-9/Bcl-2 family integrates positive and negative signals and arbitrates whether apoptosis should occur; activation of CED-4/Apaf-1 commits to apoptosis, and CED …