Jul 19, 2021 · Here, we show that basic leucine zipper ATF-like transcription factor (BATF) and interferon regulatory factor 4 (IRF4) cooperate to counter T cell exhaustion in mouse tumor models.

Jul 21, 2021 · Here, we show that basic leucine zipper ATF-like transcription factor (BATF) and interferon regulatory factor 4 (IRF4) cooperate to counter T cell exhaustion in mouse tumor models.

Expression of the transcription factor BATF reduced exhaustion of CAR T cells and sustained tumor inhibition.

Jun 21, 2013 · BATF leucine zipper motifs interact with interferon-regulatory factor 4 (IRF4) and IRF8 at AP-1–IRF consensus elements (AICEs). The discovery of the BATF–IRF interaction adds additional...

Jul 19, 2021 · New reports provide further insight into the role of the transcription factor BATF in pivoting the differentiation of CD8 + T cells away from T cell exhaustion and facilitating the transition of...

Integration with ENCODE data from lymphoblastoid cell line GM12878, demonstrates that IRF4 adopts either SPIB- or BATF-centric genome-wide distributions in related states of post-germinal centre B-cell transformation.

Integration with ENCODE data from lymphoblastoid cell line GM12878, demonstrates that IRF4 adopts either SPIB- or BATF-centric genome-wide distributions in related states of post-germinal centre B-cell transformation.

Oct 29, 2019 · In this report, we investigated the function of Batf in regulating genomic targets to initiate the programming of gene expression during the transition from naive to effector CD4 T cell.

Sep 1, 2021 · Concept: Cooperation between BATF and IRF4 enhanced tumor inhibition and promoted memory T-cell formation. Impact: Countering T-cell exhaustion via induced expression of BATF could improve the efficacy of CAR T-cell therapy.

Feb 14, 2014 · Here, we show that the interferon regulatory factor 4 (IRF4) and its cooperating binding partner B-cell-activating transcription factor (BATF) are necessary for sustained CD8 + T-cell effector function.