BAP1 tumor predisposition syndrome is caused by mutations in the BAP1 gene. The BAP1 protein acts as a tumor suppressor, which means it helps prevent cells from growing and …

Oct 13, 2016 · BAP1 tumor predisposition syndrome (BAP1-TPDS) is associated with an increased risk for a specific skin lesion, BAP1-inactivated melanocytic tumors (BIMT; formerly …

BRCA1 associated protein-1 (ubiquitin carboxy-terminal hydrolase) is a deubiquitinating enzyme that in humans is encoded by the BAP1 gene. [5] [6] BAP1 encodes an 80.4 kDa nuclear …

Dec 5, 2024 · If you have a mutation in the BAP1 gene, this means you have a condition called BAP1 tumor predisposition syndrome. BAP1 mutations increase your risk for certain types of …

The BAP1 gene provides instructions for making a protein called ubiquitin carboxyl-terminal hydrolase BAP1 (shortened to BAP1). This protein functions as a deubiquitinase, which means …

Mar 28, 2025 · BAP1 (BRCA1 Associated Deubiquitinase 1) is a Protein Coding gene. Diseases associated with BAP1 include Kury-Isidor Syndrome and Tumor Predisposition Syndrome 1. …

In summary, BAP1 is a powerful tumor suppressor gene. Carriers of germline BAP1 mutations often develop multiple cancers during their lifetime. The overall penetrance for cancer is at …

Aug 22, 2023 · BRCA1-associated protein-1 (BAP1) is a recognised tumour suppressor gene. Germline BAP1 pathogenic/likely pathogenic variants are associated with predisposition to …

BRCA1-associated protein -1 (BAP1) is a nuclear protein encoded by the BAP1 tumour -suppressor gene located on chromosome 3 (locus 3p21.1). The BAP1 protein acts as a …

Nov 15, 2021 · BAP1 tumor predisposition syndrome, also known as BAP1-TPDS or COMMON syndrome, is an inherited genetic disorder that may increase the risk of certain types of …