May 27, 2011 · By employing a receptor array assay, we have demonstrated that B7-H2, best known as the ligand of inducible costimulator, was a ligand for CD28 and CTLA-4 in human, whereas these interactions were not conserved in mouse. B7-H2 and B7-1 or B7-2 interacted with CD28 through distinctive domains.

By employing a newly developed receptor array, we have demonstrated that B7-H2, best known as the ligand of Inducible Costimulator, was a ligand for CD28 and CTLA-4 in human, whereas these interactions were not conserved in mouse.

High-quality B7-H2 proteins from ACROBiosystems. Various species and tags of B7-H2 proteins. Minimal Batch-to-Batch Variation. Bulks in stock.

Feb 13, 2024 · Advances in understanding B7:CD28 pathways have ushered in a new era of immunotherapy with effective drugs to treat cancer, autoimmune diseases, infectious diseases, and transplant rejection.

Oct 15, 2000 · The results indicate that B7-H2 is a putative ligand for the ICOS T-cell molecule. Costimulatory interactions between the B7 family ligands and their receptors play critical roles in the growth, differentiation, and death of T cells.

Mar 22, 2019 · In previous decades, novel members of the B7 family, including B7-1, B7-2, B7-H1, B7-H2, B7-H3, B7-H4 and B7-DC, have been identified. Accumulating data have demonstrated that the abnormal expression of B7 molecules is …

B7-H2 - Another New B7 Family Member B7-H2 (also called B7RP-1, B7h, LICOS and GL50) is another member of the growing B7 family of immune costimulatory proteins. 1, 3, 5, 35, 36, 37, 38 As with other B7 family members, B7-H2 is a type I protein that is a member of the Ig superfamily.

B7-H2, best known as the ligand of inducible costi-mulator,wasaligandforCD28andCTLA-4inhuman, whereas these interactions were not conserved in mouse. B7-H2 and B7-1 or B7-2 interacted with CD28 through distinctive domains. B7-H2-CD28 interaction was essential for the costimulation of human T cells’ primary responses to allogeneic anti-

In mouse spleens, B7-H2 expression on CD8 + T cells was all significantly higher than on CD4 + T cells in five time periods. So, in this study, it was found that B7-H2 expression on CD8 + T cells in tumor microenvironment was closely related to the progression of colorectal cancer.

Here, we describe the distribution of three members of the expanding family of B7 immunomodulatory molecules: B7-DC, B7-H2, and B7-H3. B7-DC and B7-H3 inhibit antigen-stimulated lymphocyte activation while B7-H2 serves in a regulatory capacity, often promoting a Th2 immunophenotype.