B7 is a type of integral membrane protein found on activated antigen-presenting cells (APC) that, when paired with either a CD28 or CD152 surface protein on a T cell, can produce a …

Jun 6, 2005 · The B7 family consists of structurally related, cell-surface protein ligands, which bind to the CD28 family of receptors on lymphocytes and regulate immune responses via …

The five new B7 family members, ICOS ligand, PD-L1 (B7-H1), PD-L2 (B7-DC), B7-H3, and B7-H4 (B7x/B7-S1) are expressed on professional antigen-presenting cells as well as on cells …

Feb 1, 2002 · New B7 and CD28 family members and new pathways have recently been identified that seem to be especially important for regulating the responses of previously activated, …

Here, we review recent understanding of B7 family members and their concerted regulation of the immune response to either self or foreign pathogens. We also discuss clinical developments in …

The B7 family members are widely expressed on tumor cells and cell populations of the tumor microenvironment. The co-inhibitory B7-H ligands promote the suppression of host anti-tumor …

The B7 family of genes is essential in the regulation of the adaptive immune system. Most B7 family members contain both variable (V)- and constant (C)-type domains of the …

The B7 family has ten members and is divided into three phylogenetically distinct groups. 1 Groups I and II are involved in central and peripheral immune tolerance, respectively.

B7-H1 (also called programmed death ligand 1, PD-L1) and PD-L2 (also called B7-DC) are two recently identified members of the B7 family. B7-H1 shares approximately 20% aa identity with …

Jun 6, 2005 · The B7 family consists of structurally related, cell-surface protein ligands, which bind to receptors on lymphocytes that regulate immune responses.