Beta-1,4-galactosyltransferase 1 is an enzyme that in humans is encoded by the B4GALT1 gene. [5][6] This gene is one of seven beta-1,4-galactosyltransferase (beta4GalT) genes.

Mar 28, 2025 · Complete information for B4GALT1 gene (Protein Coding), Beta-1,4-Galactosyltransferase 1, including: function, proteins, disorders, pathways, orthologs, and …

B4GALT1 promotes immune escape by regulating the expression of PD-L1 at multiple levels in lung adenocarcinoma. Genetic and functional evidence links a missense variant in B4GALT1 …

Jun 12, 2023 · Function and mechanism experiments in vitro and in vivo were performed to explore the regulatory mechanism of B4GALT1-mediated immune evasion by regulating …

B4GALT1-CDG is a congenital disorder of glycosylation characterised by macrocephaly due to Dandy-Walker malformation, hydrocephaly, hypotonia, myopathy and coagulation anomalies.

Jan 17, 2020 · Our data show that β4GalT1 is a crucial regulator of β1 integrin function in MKs, thrombopoiesis, and HSC homeostasis.

Feb 8, 2025 · Gene target information for B4GALT1 - beta-1,4-galactosyltransferase 1 (human). Find diseases associated with this biological target and compounds tested against it in …

Beta-1,4-galactosyltransferase 1 (B4GALT1) is a member of the β-1, 4-galactosyltransferase gene family that encodes a type II membrane-bound glycoprotein that transfers galactose to a …

Dec 2, 2021 · We identified associations between an Amish-enriched missense variant (p.Asn352Ser) in a functional domain of beta-1,4-galactosyltransferase 1 (B4GALT1) and 13.9 …

Jan 25, 2024 · By sequence similarity, the beta4GalTs form four groups: beta4GalT1 and beta4GalT2, beta4GalT3 and beta4GalT4, beta4GalT5 and beta4GalT6, and beta4GalT7. This …