Azoles are a class of five-membered heterocyclic compounds containing a nitrogen atom and at least one other non-carbon atom (i.e. nitrogen, sulfur, or oxygen) as part of the ring. [1] . Their names originate from the Hantzsch–Widman nomenclature.

Azole antifungal agents can be used to treat fungal infections of the body and skin, including athlete's foot, onychomycosis (fungal nail infections), ringworm, and vaginal candidiasis.

The azoles that are available for systemic use can be classified into two groups: the triazoles (fluconazole, itraconazole, voriconazole, posaconazole, and isavuconazole) and the imidazoles (ketoconazole). An overview of the use of azole agents for the treatment of various systemic fungal infections will be reviewed here.

Major developments in research into the azole class of antifungal agents during the 1990s have provided expanded options for the treatment of many opportunistic and endemic fungal infections. Fluconazole and itraconazole have proved to be safer than both amphotericin B …

Apr 24, 2024 · Azole antifungal medications usually kill A. fumigatus and treat infections, but antifungal resistance can develop after long-term use. Azole fungicides work similarly to kill A. fumigatus that threatens plants but can also cause A. fumigatus to become resistant.

Aug 3, 2024 · Azole antifungals are generally well tolerated but are involved in numerous drug-drug interactions. Look carefully for interactions before initiating these (use a drug-interaction tool such as 燐 MedScape's drug interaction checker .)

Azole compounds have been used for decades to treat fungal infections and are one of the most utilized classes of antifungal agents. However, researchers have been studying new strategies and techniques to obtain new antifungal drugs with improved safety and tolerability profiles, diminished drug–drug interactions, toxicity, and resistance ...

Oct 5, 2020 · The primary mechanism of action involves the inhibition of ergosterol biosynthesis, leading to the disruption of fungal cell membrane integrity. Exploring these azole antifungal agents involves covering indications, contraindications, drug interactions, and adverse event profiles.

Azoles are a broad class of five-membered heterocycles containing one or more nitrogen atoms with or without other heteroatoms in the ring. Azoles have always been considered as a scaffold of choice in designing of novel therapeutic agents.

Oct 17, 2024 · Azole antifungals are key in treating fungal infections, important in both clinical and agricultural settings. They treat a range of pathogenic fungi affecting humans and animals. However, rising resistance highlights the need to understand azoles for effective strategies against fungal pathogens.