Jun 18, 2019 · AXIN2 helps regulate the stability of a protein called beta-catenin in what’s known as the Wnt signaling pathway. The deregulation of beta-catenin can lead to the development …

The AXIN2 gene has been mapped to 17q23-q24, a region that shows frequent loss of heterozygosity in breast cancer, neuroblastoma, and other tumors. Mutations in this gene have been associated with colorectal cancer with defective mismatch repair.

Mar 30, 2025 · AXIN2 (Axin 2) is a Protein Coding gene. Diseases associated with AXIN2 include Oligodontia-Colorectal Cancer Syndrome and Axin2-Related Attenuated Familial Adenomatous Polyposis.

Mar 26, 2025 · Gene target information for AXIN2 - axin 2 (human). Find diseases associated with this biological target and compounds tested against it in bioassay experiments.

Nov 28, 2017 · HGNC Approved Gene Symbol: AXIN2. Cytogenetic location: 17q24.1 Genomic coordinates (GRCh38) : 17:65,528,563-65,561,648 (from NCBI) The Axin (603816)-related protein conductin, or axil, plays an important role in the regulation of the stability of beta-catenin (116806) in the Wnt signaling pathway.

Mar 19, 2025 · Explore how Axin2 gene mutations influence colorectal abnormalities through their impact on Wnt signaling, inheritance patterns, and diagnostic insights. Genetic mutations can significantly impact cellular processes, sometimes leading to serious health conditions.

Feb 8, 2025 · The AXIN2 gene has been mapped to 17q23-q24, a region that shows frequent loss of heterozygosity in breast cancer, neuroblastoma, and other tumors. Mutations in this gene have been associated with colorectal cancer with defective mismatch repair. …

Oct 16, 2019 · Colorectal cancer (CRC) and hypodontia are frequent and different diseases with common genes are involved in their etiology. The objective of this study was to identify the association between...

Wingless/integration signaling gene, AXIN2, is linked to tooth agenesis and also to colorectal cancer (CRC). Aims: To analyze the correlation between tooth agenesis and CRC.

Jan 31, 2024 · The colorectal polyps in individuals with AXIN2 mutations may be of different types, including adenomas and hyperplastic polyps. Individuals with AXIN2 mutations may also have missing adult teeth (oligodontia) and reduced amounts of hair on the skin and scalp.